Apr 17, 2020

Crosstalk Between Immunity System Cells and Pancreas. Transformation of Stem Cells Used in the 3D Bioprinting Process as a Personalized Treatment Method for Type 1 Diabetes

Archivum Immunologiae Et Therapiae Experimentalis
Paulina Niedźwiedzka-RystwejMichał Wszoła

Abstract

Interactions between the immune system and the pancreas are pivotal in understanding how and why β cells' damage causes problems with pancreas functioning. Pancreatic islets are crucial in maintaining glucose homeostasis in organs, tissue and cells. Autoimmune aggression towards pancreatic islets, mainly β cells, leads to type 1 diabetes-one of the most prevalent autoimmune disease in the world, being a worldwide risk to health of many people. In this review, we highlight the role of immune cells and its influence in the development of autoimmunity in Langerhans islets. Moreover, we discuss the impact of the immunological factors on future understanding possible recurrence of autoimmunity on 3D-bioprinted bionic pancreas.

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Mentioned in this Paper

Stem Cells
Pancreas
Organ
Islet Cell
World
Immune System
Immune Effector Cell
Glucose Homeostasis
Diabetes Mellitus, Insulin-Dependent
Structure of Beta Cell of Islet

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