Crosstalk Between Inflammation and Glutamate System in Depression: Signaling Pathway and Molecular Biomarkers for Ketamine's Antidepressant Effect

Molecular Neurobiology
Wenyan CuiMing D Li

Abstract

Depression is a worldwide illness with a significant impact on both family and society. Conventional antidepressants are ineffective for more than 30% of patients. In such patients, who have what is called treatment-resistant depression (TRD), inflammatory biomarkers are expressed excessively in both the central nervous system (CNS) and the peripheral blood. Ketamine, a glutamate receptor antagonist, exerts a rapid and sustained therapeutic effect in patients with TRD. Thus, the investigation of the relations between inflammation and glutamate underlying depression has drawn great attention. Inflammation influences glutamate release, transmission, and metabolism, resulting in accumulated extracellular glutamate in the CNS. Downstream of the glutamate receptors, the mammalian target of rapamycin (mTOR) signaling pathway plays a key role in mediating ketamine's antidepressant effect by improving neurogenesis and plasticity. Based on the mechanism and clinical evidence of the inflammatory contribution to the pathogenesis of depression, extensive research has been devoted to inflammatory biomarkers of the clinical response of depression to ketamine. The inconsistent findings from the biomarker investigations are at least partially ...Continue Reading

References

Jan 1, 1995·Progress in Neuro-psychopharmacology & Biological Psychiatry·M Maes
Nov 14, 1997·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·L A PembertonB J Brew
Feb 25, 2000·Biological Psychiatry·R M BermanJ H Krystal
Mar 4, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S LanquillonH Vedder
Apr 3, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lucile CapuronAndrew H Miller
Nov 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Francesco BenedettiEnrico Smeraldi
Apr 18, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Younger W-Y YuShih-Jen Tsai
Jul 28, 2004·Molecular Psychiatry·D C Javitt
Oct 8, 2004·Expert Opinion on Therapeutic Targets·Sophie Pezet, Marzia Malcangio
Aug 9, 2005·Biological Psychiatry·Dwight L EvansWilliam J Valvo
Aug 16, 2005·Progress in Neurobiology·Clive R Bramham, Elhoucine Messaoudi
Dec 1, 2005·Trends in Immunology·Charles L RaisonAndrew H Miller
Jan 5, 2006·The American Journal of Psychiatry·Madhukar H TrivediUNKNOWN STAR*D Study Team
Apr 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J Paul MonkMiguel A Villalona-Calero
Apr 25, 2006·Biological Psychiatry·Ronald S Duman, Lisa M Monteggia
Aug 9, 2006·Archives of General Psychiatry·Carlos A ZarateHusseini K Manji
Jan 16, 2007·Neurobiology of Aging·Jae-Min KimJin-Sang Yoon
Jan 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yunfei HuangSolomon H Snyder
Mar 3, 2007·Neuron·Stéphane PeineauGraham L Collingridge
May 15, 2007·Journal of Neuroscience Research·Sébastien Tilleux, Emmanuel Hermans
Sep 22, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Lêda S B GarciaJoão Quevedo
Nov 3, 2007·Progress in Neuro-psychopharmacology & Biological Psychiatry·Triin EllerEduard Maron
Dec 13, 2007·Nature Reviews. Neuroscience·Robert DantzerKeith W Kelley
Oct 4, 2008·Neuropsychobiology·V L MisenerUNKNOWN International Consortium for Childhood-Onset Mood Disorders
Jan 17, 2009·Neuron·Mauro Costa-MattioliNahum Sonenberg
Jan 20, 2009·Biological Psychiatry·Andrew H MillerCharles L Raison
Jan 24, 2009·Inflammatory Bowel Diseases·Lesley A GraffCharles N Bernstein
Feb 4, 2009·Psychosomatic Medicine·M Bryant HowrenJerry Suls
Apr 3, 2009·Journal of Affective Disorders·Jens Drachmann BukhLars Vedel Kessing

❮ Previous
Next ❯

Citations

Dec 13, 2019·Biologie aujourd'hui·Rémi Corne, Raymond Mongeau
May 14, 2019·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Sonani MindtLaura Kranaster
May 23, 2020·Metabolic Brain Disease·Lu TianPeng Xie
Jan 9, 2019·Frontiers in Psychiatry·Yinan WuAnwen Shao
Jan 10, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Esmé Jansen van VurenBrian H Harvey
Apr 3, 2020·Journal of the Neurological Sciences·Molly C KalmoeCharles R Conway
Apr 27, 2021·Pharmacology & Therapeutics·Cong-Yuan XiaWei-Ku Zhang
Jun 4, 2021·Translational Neuroscience·Nan ZhangZhongchun Liu
Aug 31, 2021·European Journal of Pharmacology·Vahid Shafiei-IrannejadHamid Soraya
Dec 12, 2021·Current Pain and Headache Reports·Jeffrey J MojicaStephanie J Nahas

❮ Previous
Next ❯

Methods Mentioned

BETA
cesarean section

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.