Crosstalk between miRNAs and their regulated genes network in stroke

Scientific Reports
Ye YuanZhong Wang

Abstract

In recent years, more and more studies focus on the roles of genes or miRNAs in stroke. However, the molecular mechanism connecting miRNAs and their targetgenes remains unclear. The aim of this study was to determine the differential regulation and correlations between miRNAs and their targetgenes in human stroke. Stroke-related miRNAs were obtained from the Human MicroRNA Disease Database (HMDD) and their targetgenes were generated from three independent sources. Kappa score was used to create the network and the functional modules. A total of 11 stroke-related miRNAs were identified from the HMDD and 441 overlapping targetgenes were extracted from the three databases. By network construction and GO analysis, 13 functional modules, 186 biological processes, and 21 pathways were found in the network, of which functional module 8 was the largest module, cellular-related process and phosphate-related process were the most important biological processes, and MAPK signaling pathway was the most significant pathway. In our study, all miRNAs regulate the stroke modular network by their targetgenes. After the validation of miRNAs, we found that miR-605 and miR-181d were highly expressed in the blood of stroke patients which never repo...Continue Reading

References

Mar 1, 1992·Stroke; a Journal of Cerebral Circulation·A R LaptookE Olivares
Aug 24, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F C Barone, G Z Feuerstein
Dec 22, 2006·Bioinformatics·Isabelle RivalsMarie-Claude Potier
Dec 1, 2007·Clinical Science·Jessica M OsmondAnne M Dorrance
Jun 26, 2009·Cellular and Molecular Life Sciences : CMLS·N KakinumaR Kiyama
Aug 12, 2009·Nature Structural & Molecular Biology·Patricia LandryPatrick Provost
Sep 12, 2009·Clinical Chemistry·Omar F LaterzaWarren E Glaab
Nov 6, 2009·PloS One·Kay Sin TanKandiah Jeyaseelan
Sep 16, 2010·Physiological Genomics·Cameron Rink, Savita Khanna
Nov 4, 2010·Nucleic Acids Research·Damian SzklarczykChristian von Mering
Aug 6, 2011·Stroke; a Journal of Cerebral Circulation·Francesco CipolloneFiamma Buttitta
Oct 11, 2011·Neurobiology of Disease·Yi-Bing OuyangRona G Giffard
Apr 3, 2012·Journal of Molecular Neuroscience : MN·Shiv S PrasadCarole Yauk
Nov 5, 2013·Trends in Cardiovascular Medicine·Xinghui SunMark W Feinberg
Apr 8, 2014·Neurochemistry International·Ke-Jie YinY Eugene Chen
Aug 12, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Shuping XiaoGuangkun Feng
Oct 22, 2014·Molecular Medicine Reports·Zhe QuanQihong Wang
Jan 15, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Fang HuaDonald G Stein

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Citations

Feb 10, 2017·Journal of Molecular Neuroscience : MN·Souvik KarHelmut Bertalanffy
Apr 28, 2018·Human Molecular Genetics·Murali VijayanP Hemachandra Reddy
Jun 7, 2018·RNA·Rachael P HuntleyRuth C Lovering
Jan 18, 2020·Briefings in Functional Genomics·Anu Radha SharmaPadmalatha S Rai
Jan 13, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Nils Henninger, Yunis Mayasi
Oct 23, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·XinWang ZhuLiNing Wang

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Methods Mentioned

BETA
PCR

Software Mentioned

Cytoscape
ClueGO
CluepediaV1
STRING
StepOne
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