Crosstalk between NRF2 and Dicer through metastasis regulating MicroRNAs; mir-34a, mir-200 family and mir-103/107 family

Archives of Biochemistry and Biophysics
Heba K Nabih

Abstract

Oxidative stress due to generation of reactive oxygen species (ROS) can cause damage to cellular proteins, lipids and DNA, which is one of crucial causes responsible for cancer. Nuclear factor erythroid 2 [NF-E2]-related factor 2 (NRF2) is a transcription factor of a variety of antioxidant and cytoprotective enzymes, so that it reduces the levels of damaging ROS in the cell. Over expression of NRF2 in cancer cells can enhance cancer progression, confer resistance to chemo and radiotherapy, and metastasis through the process of epithelial-to mesenchymal transition (EMT); which is a hallmark of cancer-related death. Dicer, a key component of the microRNAs biogenesis, is a ribonuclease enzyme which involves in maturation of microRNAs that have a role in distinct steps of metastasis cascade. Moreover, Dicer was found to be regulated by ROS/NRF2 interaction to contribute to activation of DNA damage repair mechanism. In addition, Dicer is directly reduced by mir-103/107 family that confers migratory capacity through down-regulation of mir-200 family (mir-200b/mir-200c/mir-429). Mir-200c and mir-34a were predicted to target the repressor of NRF2; Sirt1. On the other hand, mir-200a and mir-141 (mir-200 family) were detected to regulate...Continue Reading

Citations

May 9, 2021·Analytical Biochemistry·Bin WenKui Zhao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.