Crosstalk between PTGS and TGS pathways in natural antiviral immunity and disease recovery

Nature Plants
Camilla Julie KørnerManfred Heinlein

Abstract

Virus-induced diseases cause severe damage to cultivated plants, resulting in crop losses. Certain plant-virus interactions allow disease recovery at later stages of infection and have the potential to reveal important molecular targets for achieving disease control. Although recovery is known to involve antiviral RNA silencing1,2, the specific components of the many plant RNA silencing pathways 3 required for recovery are not known. We found that Arabidopsis thaliana plants infected with oilseed rape mosaic virus (ORMV) undergo symptom recovery. The recovered leaves contain infectious, replicating virus, but exhibit a loss of viral suppressor of RNA silencing (VSR) protein activity. We demonstrate that recovery depends on the 21-22 nt siRNA-mediated post-transcriptional gene silencing (PTGS) pathway and on components of a transcriptional gene silencing (TGS) pathway that is known to facilitate non-cell-autonomous silencing signalling. Collectively, our observations indicate that recovery reflects the establishment of a tolerant state in infected tissues and occurs following robust delivery of antiviral secondary siRNAs from source to sink tissues, and establishment of a dosage able to block the VSR activity involved in the for...Continue Reading

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Citations

Oct 12, 2018·Nature Reviews. Immunology·Zhongxin GuoShou-Wei Ding
Mar 3, 2018·Nature Plants·Yu Huang, Yi Li
Aug 20, 2020·Plant Molecular Biology·Melisa LeoneSebastián Asurmendi
Nov 20, 2018·Frontiers in Plant Science·Dinesh Babu Paudel, Hélène Sanfaçon
Aug 23, 2020·Plants·Roberta SpanòTiziana Mascia
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Feb 15, 2020·Scientific Reports·Roberta SpanòTiziana Mascia
Jul 10, 2019·Molecular Plant Pathology·Hernan Garcia-Ruiz
Jan 16, 2021·International Journal of Molecular Sciences·Hymavathi SalavaFatemeh Maghuly
Mar 20, 2021·Frontiers in Plant Science·Neeti Sanan-MishraSunil K Mukherjee
Dec 29, 2020·Current Opinion in Virology·Jeanmarie Verchot, Karolina M Pajerowska-Mukhtar
Apr 20, 2021·Frontiers in Plant Science·Khalid AmariManfred Heinlein
Mar 29, 2021·The New Phytologist·Aline Koch, Michael Wassenegger
May 21, 2021·The Plant Cell·Gabriele BradamanteMarco Incarbone
Jul 3, 2021·International Journal of Molecular Sciences·Konstantin V KiselevAlexandra S Dubrovina
May 14, 2021·Molecular Plant-microbe Interactions : MPMI·Giulia TarquiniGiuseppe Firrao

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Methods Mentioned

BETA
PCR
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