Crosstalk between STAT5 activation and PI3K/AKT functions in normal and transformed mammary epithelial cells

Molecular and Cellular Endocrinology
Patrick D RädlerKay-Uwe Wagner

Abstract

Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) have been shown to function downstream of several peptide hormones and cytokines that are required for postnatal development and secretory function of the mammary gland. As part of an extended network, these signal transducers can engage in crosstalk with other pathways to facilitate synergistic, and sometimes antagonistic, actions of different growth factors. Specifically, signaling through the JAK2/STAT5 cascade has been demonstrated to be indispensable for the specification, proliferation, differentiation, and survival of secretory mammary epithelial cells. Following a concise description of major cellular programs in mammary gland development and the role of growth factors that rely on JAK/STAT signaling to orchestrate these programs, this review highlights the significance of active STAT5 and its crosstalk with the PI3 kinase and AKT1 for mediating the proliferation of alveolar progenitors and survival of their functionally differentiated descendants in the mammary gland. Based on its ability to provide self-sufficiency in growth signals that are also capable of overriding intrinsic cell death programs, persistently active STAT5 can serve a...Continue Reading

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Citations

Sep 25, 2018·Molecular Human Reproduction·Jessie M SutherlandEileen A McLaughlin
Feb 3, 2019·Journal of Cellular Physiology·Dandan WangWei Wei
Apr 17, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rashmi GuptaPatricia K A Mongini
Oct 9, 2019·Journal of Huntington's Disease·Karen E AndersonUNKNOWN Huntington Study Group
Feb 23, 2020·In Vitro Cellular & Developmental Biology. Animal·Baosheng WangFeng Zhao
Aug 27, 2019·Frontiers in Cellular and Infection Microbiology·Meghana Rastogi, Sunit K Singh
Aug 5, 2020·Journal of Mammary Gland Biology and Neoplasia·Sharon Havusha-LauferItamar Barash
Jan 24, 2019·International Journal of Molecular Sciences·Vanessa Edna SanchezYong-Mi Kim
Nov 5, 2019·Frontiers in Oncology·Emira BousoikHamidreza Montazeri Aliabadi
Mar 27, 2021·Frontiers in Neuroendocrinology·G Molina-SalinasM Cerbon
May 28, 2021·Annals of the New York Academy of Sciences·Tilmann Wurtz
Jun 1, 2021·The Journal of Biological Chemistry·Sayantani GoswamiNan Gao
Nov 27, 2021·Signal Transduction and Targeted Therapy·Xiaoyi HuWei Wang

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