Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies

Stem Cell Research & Therapy
Anwen ShaoJianmin Zhang

Abstract

The injured spinal cord is difficult to repair and regenerate. Traditional treatments are not effective. Stem cells are a type of cells that have the potential to differentiate into various cells, including neurons. They exert a therapeutic effect by safely and effectively differentiating into neurons or replacing damaged cells, secreting neurotrophic factors, and inhibiting the inflammatory response. Many types of stem cells have been used for transplantation, and each has its own advantages and disadvantages. This review discusses the possible mechanisms of stem cell therapy for spinal cord injury, and the types of stem cells commonly used in experiments, to provide a reference for basic and clinical research on stem cell therapy for spinal cord injury.

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Citations

Sep 29, 2020·Cell & Bioscience·Ling Ling LiauJia Xian Law
Oct 14, 2020·Stem Cells and Development·Zhihua RenRiyi Shi
Mar 13, 2021·Stem Cell Research & Therapy·Desheng KongHuixian Cui
Jun 2, 2021·The Journal of Spinal Cord Medicine·Krishnapriya ChandrababuLissy Kalliyana Krishnan
Jun 14, 2021·Clinical Neurology and Neurosurgery·Fedor HlebokazovNatalia Goncharova

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Clinical Trials Mentioned

NCT02163876
NCT01321333

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