Crosstalk between the alpha2beta1 integrin and c-met/HGF-R regulates innate immunity

Blood
Karissa D McCall-CulbreathMary M Zutter

Abstract

Data from several investigators suggest that the alpha2beta1 integrin, a receptor for collagens, laminins, decorin, E-cadherin, matrix metalloproteinase-1, endorepellin, and several viruses, is required for innate immunity and regulation of autoimmune/allergic disorders. We demonstrated that the innate immune response to Listeria monocytogenes required alpha2beta1 integrin expression by peritoneal mast cells (PMCs). Ligation of the alpha2beta1 integrin by C1q contained in immune complexes comprised of Listeria and antibody was required for PMC activation in vitro and in vivo. However, ligation of the alpha2beta1 integrin alone was insufficient to activate cytokine secretion, suggesting that one or more additional signals emanating from a coreceptor were required for PMC activation. Here, we demonstrate that C1q, but neither other complement proteins nor FcRgamma, is required for early innate immune response to Listeria. The binding of Listeria's Internalin B (InlB) to hepatocyte growth factor receptor (HGF-R)/c-met provides the costimulatory function required for PMC activation. Either HGF or Listeria InlB bound to c-met and either C1q or type I collagen bound to alpha2beta1 integrin stimulates PMC activation. These findings su...Continue Reading

References

Jan 1, 1994·Methods in Enzymology·S A SantoroP J Keely
Nov 5, 1997·Immunity·L B KlicksteinA Nicholson-Weller
Jan 13, 1998·Nature Genetics·D GarrickE Whitelaw
Jun 13, 1998·The Journal of Clinical Investigation·S MizunoT Nakamura
Jun 2, 1998·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·E I PeerschkeB Ghebrehiwet
Feb 4, 1999·Nature Medicine·T UekiJ Fujimoto
Jun 8, 1999·Annual Review of Immunology·J P Kinet
Jun 11, 1999·Advances in Immunology·Y ShimizuM H Ginsberg
Sep 17, 1999·The American Journal of Pathology·M M ZutterE L Elson
Mar 8, 2000·The Journal of Experimental Medicine·V H SecorM A Brown
Dec 20, 2000·The Journal of Experimental Medicine·I GhiranA Nicholson-Weller
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·J L GommermanM C Carroll
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·U BaumannJ E Gessner
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H AraseL L Lanier
May 22, 2002·The Journal of Clinical Investigation·Volaluck SupajaturaHideoki Ogawa
Nov 21, 2002·Biochemical Society Transactions·E McGreal, P Gasque
Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeffrey D McCurdyJean S Marshall
Dec 20, 2003·Nature Reviews. Molecular Cell Biology·Carmen BirchmeierGeorge F Vande Woude
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter J NorsworthyMarina Botto
Jun 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brian T WipkePaul M Allen

❮ Previous
Next ❯

Citations

Apr 16, 2010·Basic Research in Cardiology·Rosalinda MadonnaRoberto Bolli
Apr 20, 2011·Journal of Innate Immunity·Karissa D McCall-CulbreathMary M Zutter
Apr 3, 2009·The Journal of Clinical Investigation·Pat Levitt, Daniel B Campbell
Apr 2, 2013·The International Journal of Biochemistry & Cell Biology·Matti LahtiJarmo Käpylä
Sep 15, 2009·Medical Hypotheses·Kevin G Becker, Stephen T Schultz
Sep 16, 2008·The International Journal of Biochemistry & Cell Biology·Jyrki HeinoMark S Johnson
Aug 25, 2009·The American Journal of Pathology·James D San AntonioRenato V Iozzo
Jun 8, 2010·Cellular & Molecular Biology Letters·Clementina AuriemmaNorma Staiano
May 7, 2011·Cell Adhesion & Migration·Pradipta GhoshMarilyn G Farquhar
May 16, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kalle SipiläJyrki Heino
Jan 15, 2015·Biomedicines·Giuditta Viticchiè, Patricia A J Muller
May 22, 2020·Frontiers in Cell and Developmental Biology·Xing HuangTingbo Liang
Sep 3, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chiara AgostinisFrancesco Tedesco
Oct 8, 2020·Pediatric Research·Olachi J Mezu-Ndubuisi, Akhil Maheshwari
Oct 30, 2020·Journal of Experimental Pharmacology·Haidar El DarsaOmar Abdel-Rahman
Mar 25, 2019·Genes & Diseases·Valery Adorno-Cruz, Huiping Liu
Jul 19, 2013·Development·Giuseppe R DiaferiaVincenzo Cirulli
Jun 22, 2021·Oncology Letters·Xiaojie SunXiangwei Meng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.