Crosstalk between the DNA damage response, histone modifications and neovascularisation.

The International Journal of Biochemistry & Cell Biology
Athanassios VassilopoulosTriantafyllos Chavakis

Abstract

Neovascularisation is critical in several malignant and inflammatory conditions, as well as in the course of eye disorders. During new vessel formation, endothelial cell functions, such as proliferation and sprouting are very important and are regulated by a variety of growth factors. The DNA damage response machinery as well as factors regulating histone modifications, such as histone deacetylases, regulate cell fate as well as gene expression. Recent evidence has pointed to potential interactions among BRCA1, H2AX and SIRT1 in these intracellular pathways and neovascularisation, which will be reviewed here.

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Citations

Dec 13, 2012·European Journal of Human Genetics : EJHG·K DanzaS Tommasi
Mar 1, 2016·The International Journal of Biochemistry & Cell Biology·Zhan GaoLi-Sheng Wang
Feb 13, 2010·Current Opinion in Pharmacology·Virginia Guarani, Michael Potente

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