Crosstalk Between the Microbiome and Gestational Immunity in Autism-Related Disorders.

DNA and Cell Biology
Matt J PaysourJohn R Lukens

Abstract

The etiologies of most neurodevelopmental disorders, including autism spectrum disorder (ASD), remain incompletely understood. However, recent epidemiological and experimental data suggest that dysregulated maternal immune activation (MIA) can impede normal brain maturation and promote the development of autism-related phenotypes. Indeed, our studies and work by others demonstrate that offspring born to pregnant animals that were exposed to immune activators develop many of the defining behavioral features of ASD, including abnormalities in social preference, communicative impairments, and repetitive/stereotyped behaviors. Although mounting evidence implicates key roles for hyperactive gestational inflammatory responses in neurodevelopmental disorders, the specific immune pathways that provoke autism-related phenotypes remain poorly described. The microbiome is recognized as a key modulator of immune responses, and emerging studies suggest that microbiota composition is a pivotal regulator of central nervous system function and disease. There has been growing speculation that changes in human microflora diversity contribute at some level to the recent rise in autism incidence. This has largely stemmed from reports of dysbiosis ...Continue Reading

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