Crosstalk between the microbiota-gut-brain axis and depression

Heliyon
Yu DuJin-Fang Ge

Abstract

Nutritional and microbiological psychiatry, especially the contribution of the gut microbiota to depression, has become a promising research field over the past several decades. An imbalance in the "microbiota-gut-brain axis", which reflects the constant bidirectional communication between the central nervous system and the gastrointestinal tract, has been used as a hypothesis to interpret the pathogenesis of depression. Alterations in gut microbiota composition could increase the permeability of the gut barrier, activate systemic inflammation and immune responses, regulate the release and efficacy of monoamine neurotransmitters, alter the activity and function of the hypothalamic-pituitary-adrenal (HPA) axis, and modify the abundance of brain-derived neurotrophic factor (BDNF), eventually leading to depression. In this article, we review changes in gut microbiota in depressive states, the association between these changes and depression-like behavior, the potential mechanism linking gut microbiota disruptions and depression, and preliminary attempts at using gut microbiota intervention for the treatment of depression. In summary, although the link between gut microbiota and depression and the potential mechanism have been disc...Continue Reading

Citations

Dec 18, 2020·Frontiers in Aging Neuroscience·Ji Yeon ChungJuhyun Song
Feb 18, 2021·Psychopharmacology·Ying YangYuanyuan Cheng
Feb 27, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Li FanXiaobo Li
Mar 5, 2021·Scientific Reports·Núria MachAlice Ruet
May 29, 2021·Brain and Behavior·Julie Kristine KnudsenSuzette Sørensen
Jul 31, 2021·World Journal of Psychiatry·Adejoke Yetunde Onaolapo, Olakunle James Onaolapo

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