Crosstalk between translesion synthesis, Fanconi anemia network, and homologous recombination repair pathways in interstrand DNA crosslink repair and development of chemoresistance.

Mutation Research. Reviews in Mutation Research
Brittany HaynesMalathy P V Shekhar

Abstract

Bifunctional alkylating and platinum based drugs are chemotherapeutic agents used to treat cancer. These agents induce DNA adducts via formation of intrastrand or interstrand (ICL) DNA crosslinks, and DNA lesions of the ICL type are particularly toxic as they block DNA replication and/or DNA transcription. However, the therapeutic efficacies of these drugs are frequently limited due to the cancer cell's enhanced ability to repair and tolerate these toxic DNA lesions. This ability to tolerate and survive the DNA damage is accomplished by a set of specialized low fidelity DNA polymerases called translesion synthesis (TLS) polymerases since high fidelity DNA polymerases are unable to replicate the damaged DNA template. TLS is a crucial initial step in ICL repair as it synthesizes DNA across the lesion thus preparing the damaged DNA template for repair by the homologous recombination (HR) pathway and Fanconi anemia (FA) network, processes critical for ICL repair. Here we review the molecular features and functional roles of TLS polymerases, discuss the collaborative interactions and cross-regulation of the TLS DNA damage tolerance pathway, the FA network and the BRCA-dependent HRR pathway, and the impact of TLS hyperactivation on d...Continue Reading

References

Apr 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C Lawrence
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·V Brabec, M Leng
Oct 1, 1995·Trends in Biochemical Sciences·D B Zamble, S J Lippard
Jun 22, 1999·Journal of Molecular Biology·C ArnaudeauD Jenssen
Feb 24, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C W Lawrence, V M Maher
Aug 23, 2001·Mutation Research·M L Dronkert, R Kanaar
Mar 22, 2002·The Lancet Oncology·P J McHughJ A Hartley
May 15, 2002·Biochemical Pharmacology·Vanessa E BelloLawrence C Panasci
Jan 9, 2003·Cancer·Blanche P Alter
May 23, 2003·Cold Spring Harbor Symposia on Quantitative Biology·T Lindahl, D E Barnes
Jul 31, 2003·Molecular Cell·Cassandra J VandenbergKetan J Patel
Aug 14, 2003·Human Molecular Genetics·Shobbir HussainChristopher G Mathew
Sep 6, 2003·International Journal of Radiation Oncology, Biology, Physics·Floris M WachtersHarm H Kampinga
Aug 18, 2004·Genes & Development·Paul R AndreassenToshiyasu Taniguchi
Sep 16, 2004·Molecular and Cellular Biology·Ranjit S BindraPeter M Glazer
Jan 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Koji NakanishiMaria Jasin
Feb 8, 2005·Molecular Cell·Sebastian M B NijmanRené Bernards
Sep 6, 2005·Chembiochem : a European Journal of Chemical Biology·Helle D Ulrich
Oct 21, 2005·Molecular and Cellular Neurosciences·Judith WeidenhoferPaul A Tooney
Oct 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Hengshan Zhang, Christopher W Lawrence
Dec 14, 2005·The Journal of Cell Biology·Craig A Leach, W Matthew Michael
Dec 17, 2005·Genes & Development·Richard D Kennedy, Alan D D'Andrea
Feb 9, 2006·Chemical Reviews·David M NollPaul S Miller
Mar 15, 2006·Nature Cell Biology·Tony T HuangAlan D D'Andrea
May 3, 2006·Cancer Research·Lonnie P SwiftSuzanne M Cutts
Jul 21, 2006·Experimental Cell Research·Alan R Lehmann
Aug 19, 2006·Molecular Cell·Yuichi J MachidaAnindya Dutta
Nov 16, 2006·PLoS Biology·Hiroshi ArakawaJean-Marie Buerstedde
Nov 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ildiko UnkLajos Haracska
Mar 17, 2007·DNA Repair·Alan R LehmannCatherine M Green

❮ Previous
Next ❯

Citations

Nov 19, 2015·Nucleic Acids Research·Anirban Mukherjee, Karen M Vasquez
Jan 31, 2016·Nucleic Acids Research·Florian RohlederCaroline Kisker
May 21, 2016·Frontiers in Genetics·André FranzThorsten Hoppe
May 6, 2016·Nature Reviews. Molecular Cell Biology·Raphael CeccaldiAlan D D'Andrea
Jun 23, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Paramasivan PoornimaThomas Efferth
Mar 21, 2018·Experimental Biology and Medicine·Muriel W Lambert
Aug 16, 2017·Journal of Cell Science·Rhea Sumpter, Beth Levine
Aug 8, 2019·Cancer·José M AmenábarChamindie Punyadeera
May 12, 2017·The Journal of Biological Chemistry·Matthew A SandersMalathy P Shekhar
Jan 24, 2019·Cancers·Giovanna Damia, Massimo Broggini
May 3, 2019·International Journal of Cancer. Journal International Du Cancer·Alanna MaguireLisa M Rimsza
May 14, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Niall M CorcoranChristopher M Hovens
May 4, 2021·Nucleic Acids Research·Monica ManciniIan Marc Bonapace
Aug 28, 2021·International Journal of Molecular Sciences·Jolanta KryczkaEwa Brzeziańska-Lasota

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Breast Cancer: Therapeutic Approaches

Several different therapeutic approaches are used to treat breast cancer. These include chemotherapy, hormonal therapy, targeted therapy, and Immunotherapy. Discover the latest research on breast cancer therapeutic approaches here.

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.