Crosstalk events in the estrogen signaling pathway may affect tamoxifen efficacy in breast cancer molecular subtypes

Computational Biology and Chemistry
Guillermo de Anda-JáureguiEnrique Hernández-Lemus

Abstract

Steroid hormones are involved on cell growth, development and differentiation. Such effects are often mediated by steroid receptors. One paradigmatic example of this coupling is the estrogen signaling pathway. Its dysregulation is involved in most tumors of the mammary gland. It is thus an important pharmacological target in breast cancer. This pathway, however, crosstalks with several other molecular pathways, a fact that may have consequences for the effectiveness of hormone modulating drug therapies, such as tamoxifen. For this work, we performed a systematic analysis of the major routes involved in crosstalk phenomena with the estrogen pathway - based on gene expression experiments (819 samples) and pathway analysis (493 samples) - for biopsy-captured tissue and contrasted in two independent datasets with in vivo and in vitro pharmacological stimulation. Our results confirm the presence of a number of crosstalk events across the estrogen signaling pathway with others that are dysregulated in different molecular subtypes of breast cancer. These may be involved in proliferation, invasiveness and apoptosis-evasion in patients. The results presented may open the way to new designs of adjuvant and neoadjuvant therapies for breas...Continue Reading

References

Dec 11, 1999·Nucleic Acids Research·M Kanehisa, S Goto
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SørlieA L Børresen-Dale
May 16, 2002·Proceedings of the National Academy of Sciences of the United States of America·Robert TibshiraniGilbert Chu
Feb 14, 2003·The New England Journal of Medicine·B Lawrence Riggs, Lynn C Hartmann
Oct 25, 2003·Oncogene·Robert ClarkeLeena A Hilakivi-Clarke
Feb 12, 2005·Molecular Endocrinology·Ellis R Levin
Jul 29, 2005·Nature·Andy J MinnJoan Massagué
Sep 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lance D MillerJonas Bergh
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
Feb 16, 2006·Journal of the National Cancer Institute·Christos SotiriouMauro Delorenzi
Jan 19, 2007·The New England Journal of Medicine·Rui LiuMichael F Clarke
May 15, 2007·Oncogene·A S DhillonW Kolch
Jun 5, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christine DesmedtUNKNOWN TRANSBIG Consortium
Feb 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joel S ParkerPhilip S Bernard
May 29, 2009·BMC Bioinformatics·Weijun LuoPeter J Woolf
Aug 20, 2009·Current Medicinal Chemistry·S Behjati, M H Frank
Jan 9, 2010·Salud pública de México·Karla Unger-Saldaña, Claudia Infante-Castañeda
Jan 19, 2010·Biochimica Et Biophysica Acta·Eun Kyung Kim, Eui-Ju Choi
Jan 26, 2010·Pathology, Research and Practice·Ivyna Bong Pau NiSharifah Noor Akmal Syed Hussain
Apr 27, 2010·Medicina clínica·Marta Cuadros, Aurora Llanos
Nov 4, 2010·The Journal of Biological Chemistry·Masaaki OyamaMariko Okada-Hatakeyama
Nov 9, 2010·Cancer Biology & Therapy·Gautam K MalhotraVimla Band
Nov 18, 2010·Nature Reviews. Cancer·Meera Swami
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jul 26, 2011·Oncogene·M GuedjC Theillet
Oct 4, 2011·The Journal of Clinical Investigation·Kornelia Polyak
Sep 7, 2012·PloS One·Karol Baca-LópezEnrique Hernández-Lemus
Sep 26, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G Viale
Mar 19, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Frederic Chibon
Apr 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yotam DrierEytan Domany
Apr 19, 2013·Journal of Biomedical Science·Yih-Fung ChenMeng-Ru Shen
May 25, 2013·Nucleic Acids Research·Jing WangBing Zhang
Aug 13, 2013·Genome Research·Michele DonatoSorin Draghici
Nov 12, 2013·Nucleic Acids Research·Minoru KanehisaMao Tanabe
Nov 20, 2013·Biomarkers in Cancer·Muaiad KittanehStefan Glück
Jan 28, 2014·British Journal of Pharmacology·I AzimiG R Monteith
May 21, 2014·Oncology Reports·Rubí Viedma-RodríguezDiego Arenas-Aranda
May 29, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harold J BursteinJennifer J Griggs
Jun 15, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Katherine L CookRobert Clarke
Sep 23, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F CardosoE Winer
Sep 24, 2014·The Breast : Official Journal of the European Society of Mastology·F CardosoE Winer

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Citations

Jan 23, 2016·Frontiers in Physiology·Jesús Espinal-EnríquezLena Ruiz-Azuara
Jan 7, 2016·Frontiers in Physiology·Miguel A García-CamposEnrique Hernández-Lemus
Jul 21, 2015·Computational Biology and Chemistry·Wentian LiMichaela Oswald
Sep 14, 2015·Computational Biology and Chemistry·Enrique Hernández-LemusPablo Meyer
Dec 6, 2017·Frontiers in Physiology·Sergio Antonio Alcalá-CoronaEnrique Hernández-Lemus
May 13, 2017·Scientific Reports·Jesús Espinal-EnríquezEnrique Hernández-Lemus
Mar 3, 2020·Frontiers in Oncology·Erandi A Serrano-CarbajalEnrique Hernández-Lemus
Oct 27, 2018·Frontiers in Physiology·Sergio Antonio Alcalá-CoronaEnrique Hernández-Lemus
Mar 17, 2018·Frontiers in Physiology·Guillermo de Anda-JáureguiJunguk Hur
Jul 20, 2016·Molecular Oncology·A SonnenblickM Piccart
Jan 5, 2021·Frontiers in Physiology·Laura Gómez-RomeroEnrique Hernández-Lemus
Feb 2, 2021·Frontiers in Oncology·Enrique Hernández-Lemus, Mireya Martínez-García
Apr 15, 2021·Scientific Reports·Kevin M BlumChristopher K Breuer

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