Crosstalk mechanisms between the WNT signaling pathway and long non-coding RNAs

Non-coding RNA Research
Vasiliki ZarkouPantelis Hatzis

Abstract

The WNT/β-catenin signaling pathway controls a plethora of biological processes throughout animal development and adult life. Because of its fundamental role during animal lifespan, the WNT pathway is subject to strict positive and negative multi-layered regulation, while its aberrant activity causes a wide range of pathologies, including cancer. At present, despite the inroads into the molecules involved in WNT-mediated transcriptional responses, the fine-tuning of WNT pathway activity and the totality of its target genes have not been fully elucidated. Over the past few years, long non-coding RNAs (lncRNAs), RNA transcripts longer that 200nt that do not code for proteins, have emerged as significant transcriptional regulators. Recent studies show that lncRNAs can modulate WNT pathway outcome by affecting gene expression through diversified mechanisms, from the transcriptional to post-translational level. In this review, we selectively discuss those lncRNA-mediated mechanisms we believe the most important to WNT pathway modulation.

Citations

Mar 26, 2019·Human Antibodies·Zahra AziziElahe Motevaseli
Dec 28, 2019·Human & Experimental Toxicology·A KaramianM G Novin
Nov 17, 2019·Proceedings of the National Academy of Sciences of the United States of America·Bo-Hyun YouJin-Wu Nam
Apr 21, 2019·Cancers·Elke KaemmererNikolaus Gassler
Aug 28, 2020·Frontiers in Cell and Developmental Biology·Wenjian ChenJun Sun
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Jan 27, 2021·Reproduction in Domestic Animals = Zuchthygiene·Cai-Xia YangZhi-Qiang Du
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Methods Mentioned

BETA
ubiquitination
antisense oligonucleotides
acetylation
nuclear translocation

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