Crossveinless d is a vitellogenin-like lipoprotein that binds BMPs and HSPGs, and is required for normal BMP signaling in the Drosophila wing.

Development
Jun ChenSeth S Blair

Abstract

The sensitivity of the posterior crossvein in the pupal wing of Drosophila to reductions in the levels and range of BMP signaling has been used to isolate and characterize novel regulators of this pathway. We show here that crossveinless d (cv-d) mutations, which disrupt BMP signaling during the development of the posterior crossvein, mutate a lipoprotein that is similar to the vitellogenins that comprise the major constituents of yolk in animal embryos. Cv-d is made in the liver-like fat body and other tissues, and can diffuse into the pupal wing via the hemolymph. Cv-d binds to the BMPs Dpp and Gbb through its Vg domain, and to heparan sulfate proteoglycans, which are well-known for their role in BMP movement and accumulation in the wing. Cv-d acts over a long range in vivo, and does not have BMP co-receptor-like activity in vitro. We suggest that, instead, it affects the range of BMP movement in the pupal wing, probably as part of a lipid-BMP-lipoprotein complex, similar to the role proposed for the apolipophorin lipid transport proteins in Hedgehog and Wnt movement.

References

Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·C P SchonbaumA P Mahowald
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·M HallK Söderhäll
Mar 23, 2001·The Journal of Biological Chemistry·H KirkpatrickA Laughon
Mar 7, 2003·Development·Momoko FujiseHiroshi Nakato
Feb 26, 2004·Nature Genetics·Annette L ParksHelen L Francis-Lang
Jun 10, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Mika KamimuraToshihiko Ogura
Mar 16, 2005·Developmental Biology·Amy Ralston, Seth S Blair
May 6, 2005·Nature·Daniela PanákováSuzanne Eaton
Aug 20, 2005·The Journal of Biological Chemistry·Sheng GaoAllen Laughon
Mar 23, 2006·Insect Biochemistry and Molecular Biology·Rolf Ziegler, Rik Van Antwerpen
Dec 7, 2006·Journal of Lipid Research·Marcel M W SmolenaarsDick J Van der Horst
May 18, 2007·Annual Review of Cell and Developmental Biology·Seth S Blair
May 31, 2007·Nature Genetics·Venkateswara R ChintapalliJulian A T Dow
Jul 5, 2007·Developmental Cell·Christina EugsterSuzanne Eaton
Sep 16, 2008·Journal of Insect Physiology·Muhammad Tufail, Makio Takeda
Oct 27, 2009·Development·David UmulisSeth S Blair
Nov 13, 2009·Development·Helena KhaliullinaSuzanne Eaton
Nov 16, 2010·The International Journal of Biochemistry & Cell Biology·Shicui ZhangLi Li

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Citations

Dec 12, 2012·Human Molecular Genetics·Nicolás Guillermo SantanderDolores Busso
May 24, 2013·Journal of Biochemistry·Osamu Shimmi, Stuart J Newfeld
Jul 11, 2013·PloS One·Björn HandkeChristian F Lehner
Jul 11, 2014·Proceedings. Biological Sciences·Osamu ShimmiMasatsugu Hatakeyama
Oct 29, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Isao Matsuo, Chiharu Kimura-Yoshida
Jun 6, 2013·Current Opinion in Genetics & Development·Kristi A Wharton, Mihaela Serpe
Apr 1, 2014·Methods : a Companion to Methods in Enzymology·Aidan J Peterson, Michael B O'Connor
May 27, 2010·PloS One·Krisztian KvellJudit E Pongracz
Jan 10, 2013·PloS One·Afonso Rocha Martins AlmeidaHenrique Veiga-Fernandes
May 21, 2010·Current Opinion in Pharmacology·Tracy S P HengRichard L Boyd
Aug 12, 2014·F1000Research·Yingxue Ren, Kimberly A Hughes
Jan 29, 2017·Cold Spring Harbor Perspectives in Biology·Ambuj UpadhyayMichael B O'Connor
Nov 8, 2020·Nature Communications·Katja RustTodd G Nystul
Nov 8, 2012·Development·Thomas E WillnowAnnette Hammes

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