Croton ruizianus: platelet proaggregating activity of two new pregnane glycosides

Journal of Natural Products
S PiacenteV De Feo

Abstract

The MeOH extract of the aerial parts of Croton ruizianus afforded two new pregnane glycosides 1 and 2, together with the morphinandienone alkaloids flavinantine (3) and O-methylflavinantine (4). Their structures were elucidated by NMR experiments including 1H-1H (1D TOCSY and 2D DQF-COSY) and 1H-13C (HSQC, HMBC) spectroscopy. The proaggregating activity of the MeOH extract and the isolates were evaluated. Although the MeOH extract and pregnane glycosides (at different doses) were found to promote platelet aggregation, flavinantine (3) and O-methylflavinantine (4) showed only slight activity. The ability of the MeOH extract and the four compounds to act synergistically with thrombin was also evaluated. All the tested compounds were successful in augmenting the aggregating effect of thrombin, although to different degrees.

References

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Jul 1, 1995·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·L PietersA Vlietinck

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Citations

Jun 8, 2001·Phytochemistry·H A HassanH Miyaoka
Nov 25, 2000·Journal of Ethnopharmacology·J G GrahamN R Farnsworth
Aug 7, 2003·Journal of Ethnopharmacology·Alírica I SuárezGustavo Bruges
Sep 8, 2009·Natural Product Research·Versha GuptaNaveen K Khare
Jun 7, 2011·Natural Product Research·Versha GuptaNaveen K Khare
Oct 16, 2012·Natural Product Research·Mamdouh Abdel-Mogib, Hanaa M Raghib
Jul 17, 2015·Natural Product Research·Pawan K SrivastavaNaveen K Khare
Dec 7, 2007·Journal of Ethnopharmacology·Deepika GuptaRajinder K Gupta
Apr 24, 2007·Phytochemistry·Essam Abdel-SattarMohammad Abdul-Aziz Al-Yahya
Aug 3, 2005·Journal of Ethnopharmacology·G InnocentiR Della Loggia
Jul 11, 2008·Phytochemistry·Essam Abdel-SattarHaruki Yamada
Jan 17, 2012·Fitoterapia·Angela PerroneSonia Piacente
Mar 30, 2005·Rapid Communications in Mass Spectrometry : RCM·Fabrizio Dal PiazNunziatina De Tommasi

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