Crowdsourced Identification of Possible Allergy-Associated Factors: Automated Hypothesis Generation and Validation Using Crowdsourcing Services

JMIR Research Protocols
Eiji AramakiShin-Ichiro Kumagaya

Abstract

Hypothesis generation is an essential task for clinical research, and it can require years of research experience to formulate a meaningful hypothesis. Recent studies have endeavored to apply crowdsourcing to generate novel hypotheses for research. In this study, we apply crowdsourcing to explore previously unknown allergy-associated factors. In this study, we aimed to collect and test hypotheses of unknown allergy-associated factors using a crowdsourcing service. Using a series of questionnaires, we asked crowdsourcing participants to provide hypotheses on associated factors for seven different allergies, and validated the candidate hypotheses with odds ratios calculated for each associated factor. We repeated this abductive validation process to identify a set of reliable hypotheses. We obtained two primary findings: (1) crowdsourcing showed that 8 of the 13 known hypothesized allergy risks were statically significant; and (2) among the total of 157 hypotheses generated by the crowdsourcing service, 75 hypotheses were statistically significant allergy-associated factors, comprising the 8 known risks and 53 previously unknown allergy-associated factors. These findings suggest that there are still many topics to be examined in ...Continue Reading

References

Oct 1, 1983·The Journal of Allergy and Clinical Immunology·H S NoveyI D Wells
Feb 1, 1997·Pediatric Clinics of North America·A Gupta, L K Waldhauser
Apr 8, 1999·Thorax·I S Farooqi, J M Hopkin
Jul 7, 2000·The New England Journal of Medicine·P J Delves, I M Roitt
May 8, 2004·The Journal of Allergy and Clinical Immunology·Hugh A Sampson
Apr 25, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S F BloomfieldJ Pickup
Sep 25, 2007·Chest·Vincenzo BelliaRaffaele Antonelli Incalzi
Mar 25, 2008·Therapeutics and Clinical Risk Management·De-Yun Wang
Jul 9, 2008·Annals of Medicine·Alexandros P Grammatikos
Apr 27, 2010·Clinical and Experimental Immunology·H OkadaJ-F Bach
Apr 29, 2010·Current Allergy and Asthma Reports·Angela M Haas
Jul 26, 2011·Lancet·Alexander N GreinerGlenis K Scadding
Mar 31, 2012·Chest·John A BurgessShyamali C Dharmage
Apr 18, 2012·Clinics in Dermatology·Madhulika A Gupta, Aditya K Gupta
Oct 9, 2012·American Journal of Clinical Dermatology·April W ArmstrongClayton W Schupp
Jan 21, 2014·American Journal of Preventive Medicine·Daren C BrabhamJay M Bernhardt
Feb 8, 2014·PloS One·Kirsten E BevelanderBrian Wansink
Feb 22, 2014·The Journal of Surgical Research·Carolyn ChenThomas Lendvay
Sep 2, 2014·The Journal of Allergy and Clinical Immunology·Hugh A SampsonRobert Wood
Sep 3, 2014·Allergology International : Official Journal of the Japanese Society of Allergology·Atsuo UrisuUNKNOWN Japanese Society of Allergology
Apr 25, 2016·Respiratory Investigation·Suguru SatoMitsuru Munakata
Jan 1, 2014·Allergology International : Official Journal of the Japanese Society of Allergology·Atsuo UrisuUNKNOWN Japanese Society of Allergology

❮ Previous
Next ❯

Citations

May 17, 2018·Journal of Medical Internet Research·Perrine CréquitPhilippe Ravaud

❮ Previous
Next ❯

Software Mentioned

Yahoo
! Crowdsourcing Service

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Studies in Health Technology and Informatics
Eiji AramakiShinichiro Kumagaya
The Journal of Manual & Manipulative Therapy
Chad Cook
Evaluation and Program Planning
Tarek Azzam, Elena Harman
Dermatology Online Journal
April W ArmstrongC W Schupp
© 2022 Meta ULC. All rights reserved