Crowdsourced validation of a machine-learning classification system for autism and ADHD.

Translational Psychiatry
M DudaD P Wall

Abstract

Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) together affect >10% of the children in the United States, but considerable behavioral overlaps between the two disorders can often complicate differential diagnosis. Currently, there is no screening test designed to differentiate between the two disorders, and with waiting times from initial suspicion to diagnosis upwards of a year, methods to quickly and accurately assess risk for these and other developmental disorders are desperately needed. In a previous study, we found that four machine-learning algorithms were able to accurately (area under the curve (AUC)>0.96) distinguish ASD from ADHD using only a small subset of items from the Social Responsiveness Scale (SRS). Here, we expand upon our prior work by including a novel crowdsourced data set of responses to our predefined top 15 SRS-derived questions from parents of children with ASD (n=248) or ADHD (n=174) to improve our model's capability to generalize to new, 'real-world' data. By mixing these novel survey data with our initial archival sample (n=3417) and performing repeated cross-validation with subsampling, we created a classification algorithm that performs with AUC=0.89±0.01 using...Continue Reading

References

May 11, 2006·Journal of Developmental and Behavioral Pediatrics : JDBP·Lisa D WigginsCatherine Rice
Jun 7, 2006·Archives of General Psychiatry·Catherine LordAndrew Pickles
Dec 21, 2006·Journal of Autism and Developmental Disorders·Katherine GothamCatherine Lord
Oct 10, 2007·Journal of Autism and Developmental Disorders·Jamie M KleinmanDeborah Fein
Mar 18, 2011·Developmental Neurorehabilitation·Alison M KozlowskiDaniene Neal
Jul 27, 2012·Translational Psychiatry·D P WallV A Fusaro
Dec 18, 2013·Journal of the American Academy of Child and Adolescent Psychiatry·Susanna N VisserStephen J Blumberg
Jun 10, 2014·Journal of Paediatrics and Child Health·Carly VenessSheena Reilly
Feb 10, 2016·Translational Psychiatry·M DudaD P Wall

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Citations

May 4, 2018·Psychiatry and Clinical Neurosciences·Oliver GrimmAndreas Reif
Nov 5, 2019·Child Development·Kaila C BruerKang Lee
Sep 12, 2020·Schizophrenia Bulletin·Gonzalo Salazar de PabloPaolo Fusar-Poli
Jul 1, 2020·Soa--chʻŏngsonyŏn Chŏngsin Ŭihak = Journal of Child & Adolescent Psychiatry·Da-Yea SongHee Jeong Yoo
Oct 18, 2020·Children·Harshini Sewani, Rasha Kashef

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Software Mentioned

RedCap
ENet
Elastic
Scikit Learn

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