CRP and a biomarker of type I collagen degradation, C1M, can differentiate anti-inflammatory treatment response in ankylosing spondylitis

Biomarkers in Medicine
A S SiebuhrKurt de Vlam

Abstract

To investigate if tissue turnover biomarkers were efficacy biomarkers in ankylosing spondylitis and if the biomarkers at baseline predicted a good outcome (BASDAI50). Twenty-two etanercept treated ankylosing spondylitis patients were investigated for inflammation (CRP, ESR, CRPM) and tissue turnover (C1M, C2M, C3M) during the first year of treatment. Biomarkers profiles and treatment response were investigated. ESR, CRP, BASDAI and C1M were decreased with treatment (p ≤ 0.04). C1M and CRP segregated patients into two populations predicting treatment efficacy. C1M and CRP were efficacy biomarkers and baseline biomarkers could select who benefited (by biomarkers) from treatment. C1M was not superior to CRP, but the biomarkers evaluate different pathologic events, indicating that C1M and CRP identify different events.

References

Aug 31, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·R MyllyläK I Kivirikko
Aug 15, 2002·Annals of the Rheumatic Diseases·A SpoorenbergS van der Linden
Aug 30, 2005·Annals of the Rheumatic Diseases·J ZochlingUNKNOWN European League Against Rheumatism
Jul 30, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Sanne S VeidalMorten A Karsdal
Nov 3, 2010·Best Practice & Research. Clinical Rheumatology·Rik J U LoriesFrank P Luyten
Oct 13, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Dj LeemingMa Karsdal
Apr 11, 2012·Nature Reviews. Rheumatology·Joachim Sieper
Jun 28, 2013·The Journal of International Medical Research·Mohammed HammoudehAndrew S Koenig
Aug 13, 2013·Seminars in Arthritis and Rheumatism·Anne C Bay-JensenMorten A Karsdal
Aug 16, 2013·Arthritis Research & Therapy·Anne Sofie SiebuhrMorten A Karsdal

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Citations

Apr 19, 2018·Arthritis & Rheumatology·Cecilie F Kjelgaard-PetersenAnne-C Bay-Jensen
Dec 19, 2019·Expert Review of Molecular Diagnostics·Anne Christine Bay-JensenMorten Asser Karsdal
Jul 2, 2020·Nature Reviews. Rheumatology·Matthew A BrownKim-Anh Lê Cao
Jan 25, 2021·Autoimmunity Reviews·Solveig Skovlund GroenSigne Holm Nielsen

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Methods Mentioned

BETA
ESR
ELISA
ELISAs

Software Mentioned

MedCalc

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