Abstract
The metabolic syndrome (MetS) confers an increased risk for diabetes and cardiovascular disease. Although high-sensitive C-reactive protein (hsCRP) concentrations are higher and adiponectin concentrations lower in MetS, there is no reliable biochemical measure that can capture its various features. We evaluated whether hsCRP, adiponectin, or the ratio of adiponectin or its oligomers, especially the high-molecular-weight (HMW) oligomer, to hsCRP predict MetS in 123 subjects with MetS compared with that in 91 healthy control subjects. MetS subjects had significantly higher hsCRP levels and lower total adiponectin and oligomer levels relative to control subjects (P < .0001). The HMW/total adiponectin and adiponectin/CRP ratios were significantly lower in MetS subjects than control subjects (P < .005). The odds ratio (OR) of MetS using the 75th percentile cutoff for CRP was 3.8 (95% confidence interval [CI], 2.1-6.8) and equivalent to low total adiponectin (OR, 2.5; 95% CI, 1.3-4.5), its oligomers, or the adiponectin/ hsCRP ratio (OR, 2.6; 95% CI, 1.5, 4.8). Thus, measurements of CRP, adiponectin, or its oligomers provide robust biomarkers for predicting MetS.
Citations
Apr 11, 2014·Nephro-urology Monthly·Omid Sedighi, Saeid Abediankenari
Dec 18, 2014·Diabetology & Metabolic Syndrome·Larisa LitvinovaElena Kirienkova
Jun 15, 2010·Journal of Atherosclerosis and Thrombosis·Yoshifumi SaishoHiroshi Itoh
Apr 17, 2009·Current Opinion in Lipidology·Sridevi DevarajIshwarlal Jialal
May 6, 2011·Trials·Alison J DunkleyKamlesh Khunti
Sep 27, 2013·PloS One·Yoshifumi SaishoHiroshi Itoh
Jul 2, 2011·Acta Diabetologica·Eiji Oda
Dec 11, 2008·Metabolic Syndrome and Related Disorders·Ike S Okosun
Dec 12, 2012·European Journal of Endocrinology·Triin EglitTarvo Rajasalu
Feb 7, 2016·Cardiovascular Diabetology·Mohamed Abu-FarhaNaser Elkum
Jan 26, 2016·Metabolic Syndrome and Related Disorders·Harry Robberecht, Nina Hermans
Jul 17, 2009·American Journal of Clinical Pathology·Ishwarlal Jialal
Jun 16, 2015·International Journal of Endocrinology·Dagmar HorákováHelena Kollárová
May 12, 2015·Journal of Diabetes Research·Richard G PetersonMichael K Hansen
Nov 17, 2009·Clinical Pharmacology and Therapeutics·C M Kusminski, P E Scherer
Dec 15, 2010·Nutrition & Metabolism·Alistair V NunnJimmy D Bell
Sep 18, 2017·Acta Diabetologica·Pi-Jun YanZhi-Hong Zhang
Mar 19, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Sridevi Devaraj, Ishwarlal Jialal
May 3, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Sridevi DevarajIshwarlal Jialal
Aug 3, 2013·Clinical Nutrition Research·Yun-Jung BaeMi-Kyung Sung
Feb 10, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Andrew N Margioris
Sep 19, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Yanhua PengMichel M Murr
Nov 20, 2013·European Journal of Clinical Investigation·Jan WesterinkFrank L J Visseren
Aug 20, 2015·Medicine·Hossein DarabiIraj Nabipour
Jan 22, 2018·Hormone Molecular Biology and Clinical Investigation·Ishwarlal Jialal, Sridevi Devaraj
Aug 25, 2020·Endocrine Research·Julie Shafer-EggletonIshwarlal Jialal
Oct 28, 2010·Molecular and Cellular Biochemistry·Haiyun SunChangqing Xu
Feb 13, 2016·PloS One·Supanee ThanakunYuichi Izumi
May 4, 2018·Disease Markers·Pijun YanZhihong Zhang
Oct 13, 2020·Journal of Clinical Biochemistry and Nutrition·Chung Hyun TaeSun Ha Jee
Feb 23, 2021·Journal of Nutritional Science and Vitaminology·Ikawati SulistyaningsihNinik Rustanti
Dec 17, 2010·Clinical Biochemistry·Anna StefanskaMalgorzata Cwiklinska-Jurkowska
Jun 4, 2021·Endocrine Research·Ishwarlal Jialal, Beverley Adams-Huet
Apr 11, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·G D NorataA L Catapano
May 13, 2009·Current Opinion in Lipidology