CRP and ASDAS are associated with future elevated arterial stiffness, a risk marker of cardiovascular disease, in patients with ankylosing spondylitis: results after 5-year follow-up

Annals of the Rheumatic Diseases
Inger Jorid BergSella Aarrestad Provan

Abstract

To identify factors associated with elevated arterial stiffness in a 5-year follow-up of patients with ankylosing spondylitis (AS). C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), Bath AS disease activity index (BASDAI) and AS disease activity score (ASDAS) were recorded in 2003, and arterial stiffness (Augmentation Index (AIx) and pulse wave velocity (PWV)) in 2008/2009. Patients were grouped into quartiles according to baseline CRP, ESR and BASDAI and four ASDAS groups. Trend analyses were performed using ANCOVA (AIx/PWV as dependent variable) with separate models for CRP, ESR, BASDAI and ASDAS (age and gender adjusted). Independent predictors of future AIx and PWV levels were identified in multivariate linear regression models. In total, 85 patients participated. Increasing baseline values of CRP, ESR and ASDAS were associated with elevated AIx on follow-up (p(trend) 0.01, 0.05 and 0.04, respectively). Similar non-significant patterns were seen for PWV. In the multivariate analyses, baseline CRP and ASDAS were independently associated with future elevated AIx (p=0.03 and0.02, respectively). In the multivariate PWV model, results for CRP and ASDAS were non-significant. Baseline CRP and ASDAS were associated wi...Continue Reading

References

Jan 14, 2005·Journal of Human Hypertension·C M McEniery, I B Wilkinson
Nov 1, 2005·Journal of the American College of Cardiology·Carmel M McEnieryUNKNOWN ACCT Investigators
Sep 27, 2006·European Heart Journal·Stephane LaurentUNKNOWN European Network for Non-invasive Investigation of Large Arteries
Nov 28, 2007·Annual Review of Pathology·Göran K HanssonCecilia Söderberg-Nauclér
Mar 4, 2010·European Heart Journal·Charalambos VlachopoulosChristodoulos Stefanadis
Nov 12, 2010·Annals of the Rheumatic Diseases·Pedro MachadoUNKNOWN Assessment of SpondyloArthritis international Society
Jan 18, 2011·The Journal of Rheumatology·Nóra BodnárSándor Szántó
May 5, 2011·Annals of the Rheumatic Diseases·J BraunD van der Heijde
Jul 26, 2011·Annals of the Rheumatic Diseases·Gunnstein BaklandJohannes C Nossent
Feb 22, 2012·Nature Reviews. Rheumatology·György KerekesZoltán Szekanecz

❮ Previous
Next ❯

Citations

Nov 2, 2016·Scandinavian Journal of Rheumatology·A TuttolomondoA Pinto
Sep 6, 2018·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Hatice Kaplanoglu, Cem Özişler
May 16, 2019·Current Opinion in Rheumatology·Pedro M Machado, Atul Deodhar
Sep 23, 2018·Arthritis Care & Research·Helga MidtbøEva Gerdts
Jan 17, 2019·The Journal of Rheumatology·Mohammad H DerakhshanUNKNOWN BRITSpA and COMOSPA Investigators
Sep 18, 2020·Cardiology in the Young·Reyhan DedeogluOzgur Kasapcopur
Jul 31, 2018·Echocardiography·Selin OzenAyse P Yalcin
Jun 30, 2018·International Journal of Molecular Sciences·Aikaterini AridaPetros P Sfikakis
Feb 20, 2021·Seminars in Arthritis and Rheumatism·Iñigo González MazónMiguel Angel González-Gay

❮ Previous
Next ❯

Related Concepts

Related Feeds

Angelman Syndrome

Angelman syndrome is a neurogenetic imprinting disorder caused by loss of the maternally inherited UBE3A gene and is characterized by generalized epilepsy, limited expressive speech, sleep dysfunction, and movement disorders. Here is the latest research.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.