CRP gene variation and risk of community-acquired pneumonia.

Respirology : Official Journal of the Asian Pacific Society of Respirology
Kenneth J MukamalEric B Rimm

Abstract

CRP has several potentially antibacterial effects, and variation in the CRP gene is known to influence CRP levels. Whether this variation influences risk of infection, and hence whether CRP has anti-infective activity in humans, is uncertain. We evaluated a series of haplotype-tagging single nucleotide polymorphisms among 5374 individuals in the Cardiovascular Health Study, a cohort of older adults from four communities, who were followed for community-acquired pneumonia for 12-13 years. Secondarily, we evaluated whether these polymorphisms varied among men in the Health Professionals Follow-up Study who self-reported pneumonia on biennial questionnaires. There were 581 (507 white and 74 black) Cardiovascular Health Study participants with incident hospitalizations for pneumonia. No single nucleotide polymorphism or haplotypes were associated with risk among white Cardiovascular Health Study participants. Among black participants, the haplotype tagged by A790T was associated with lower risk of incident pneumonia (hazard ratio 0.5; 95% confidence interval: 0.3-0.9) and with higher CRP levels. In Health Professionals Follow-up Study, a separate haplotype was associated with less frequent self-reported pneumonia but not with circu...Continue Reading

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Citations

Feb 1, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Chi Chiu LeungStephen G Spiro
Oct 31, 2012·Gene·Lyubov E SalnikovaAlexander V Rubanovich
Feb 16, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Lyubov E SalnikovaAlexander V Rubanovich
Sep 19, 2014·Nature·Bjorn R Olsen
Sep 27, 2013·Molecular Biology Reports·Lyubov E SalnikovaViktor V Moroz
Dec 22, 2011·Critical Reviews in Clinical Laboratory Sciences·Li Ping Chung, Grant W Waterer
Nov 22, 2018·Frontiers in Immunology·Mark B Pepys
Aug 31, 2021·Genetics and Molecular Biology·Qiaolian LiSong Li

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