Crucial parameter of the outcome in Crimean Congo hemorrhagic fever: Viral load

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
I HasanogluM A Tasyaran

Abstract

Crimean Congo hemorrhagic fever (CCHF) is a fatal disease with a mortality rate of 5-30%. CCHF can be asymptomatic or it may progress with bleeding and cause mortality. To evaluate relation of viral load with mortality, clinical and laboratory findings in CCHF. A total of 126 CCHF patients were included. Serum samples obtained from all patients on admission for measurement of viral load. In our study, mortality rate was 11.1%. The most important prognostic factor was viral load. Mean viral load was 8.3×10(7)copy/ml and 4.6×10(9)copy/ml in survived and dead patients, respectively (p<0.005). Probability of survival is found to be significantly reduced where AST >1130U/l, ALT >490U/l, CPK >505U/l, LDH >980U/l, platelet count <23×10(3)/l, creatinine >1.4mg/dl, INR >1.3, d-dimer >7100ng/dl, and viral load >1.03×10(8)copy/ml. Patients with 10(8)copy/ml or higher viral load had diarrhea, headache, unconsciousness, bleeding, and seizure significantly more frequently (p<0.05). WBC, hemoglobin, platelet counts were significantly lower whereas AST, ALT, CPK, LDH, creatinine levels, PT and aPTT time, d-dimer levels, and INR were found to be significantly higher in these group. There are several severity criteria for prognosis of CCHF. In a...Continue Reading

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Citations

Jul 6, 2016·Antiviral Research·Esragul AkinciHakan Leblebicioglu
Jul 19, 2016·Antiviral Research·Hakan LeblebiciogluUNKNOWN Crimean Congo Hemorrhagic Fever Research Network of Turkey
Nov 13, 2018·F1000Research·David W Hawman, Heinz Feldmann
Feb 7, 2019·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Barbara BartoliniAntonino Di Caro
Nov 2, 2017·Journal of Medical Virology·Imran HasanogluMehmet A Tasyaran
Jul 21, 2017·Emerging Infectious Diseases·Ronald B ReislerAnthony P Cardile
Jan 23, 2019·Emerging Infectious Diseases·Salih AhmetiPetra Emmerich
Mar 19, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Dilek Yagci-CaglayikAykut Ozkul
Oct 15, 2019·Médecine et maladies infectieuses·P FillâtreP Tattevin
Sep 20, 2020·Antiviral Research·Koray ErgünayAykut Özkul
Sep 7, 2020·Travel Medicine and Infectious Disease·Enrica SerretielloMassimiliano Galdiero
Dec 22, 2020·Current Medical Imaging·Hamid Owaysee OsqueeFereshteh Ansari

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