Crucial role of Plexin C1 for pulmonary inflammation and survival during lung injury

Mucosal Immunology
T GranjaPeter Rosenberger

Abstract

Acute pulmonary inflammation during lung injury is initiated by the migration of neutrophils into the alveolar space. The severity of these inflammatory changes within the pulmonary tissue determines the severity of lung injury and ultimately patient outcome. Recent work has demonstrated that the guidance protein Semaphorin 7A propagates the infiltration of neutrophils into an hypoxic tissue site, yet the role of its target receptor Plexin C1 (PLXNC1) during lung injury is to date unknown. We demonstrate here that PLXNC1(+) neutrophils are present within the alveolar space and that PLXNC1 is induced in vitro and in vivo during lung injury. In a model of high-pressure ventilation PLXNC1(-/-) animals show decreased signs of alveolar inflammation and improved survival compared with wild-type controls. Studies employing chimeric animals identified the hematopoietic expression of PLXNC1 to be of crucial importance for the observed results. Functional inhibition of PLXNC1 resulted in improved survival and ameliorated the signs of inflammation within the lung. Furthermore, the injection of a peptide binding to PLXNC1 resulted in improved survival and attenuated pulmonary inflammation. As such we demonstrate here, that previously unkno...Continue Reading

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Citations

Aug 18, 2017·American Journal of Respiratory Cell and Molecular Biology·Hesam MovassaghAbdelilah S Gounni
Jan 12, 2016·PloS One·Judith Marlene RothPeter Rosenberger
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Sep 10, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xueyan PengErica L Herzog
Aug 26, 2020·Chinese Journal of Integrative Medicine·Yan-Jie TuAi-Dong Yang
Jan 18, 2017·PloS One·Stephane EsnaultNizar N Jarjour
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Mar 15, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nathaniel K BergXiaoyi Yuan

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