Crude Aloe vera Gel Shows Antioxidant Propensities and Inhibits Pancreatic Lipase and Glucose Movement In Vitro

Advances in Pharmacological Sciences
Urmeela Taukoorah, M F Mahomoodally

Abstract

Aloe vera gel (AVG) is traditionally used in the management of diabetes, obesity, and infectious diseases. The present study aimed to investigate the inhibitory potential of AVG against α-amylase, α-glucosidase, and pancreatic lipase activity in vitro. Enzyme kinetic studies using Michaelis-Menten (K m ) and Lineweaver-Burk equations were used to establish the type of inhibition. The antioxidant capacity of AVG was evaluated for its ferric reducing power, 2-diphenyl-2-picrylhydrazyl hydrate scavenging ability, nitric oxide scavenging power, and xanthine oxidase inhibitory activity. The glucose entrapment ability, antimicrobial activity, and total phenolic, flavonoid, tannin, and anthocyanin content were also determined. AVG showed a significantly higher percentage inhibition (85.56 ± 0.91) of pancreatic lipase compared to Orlistat. AVG was found to increase the Michaelis-Menten constant and decreased the maximal velocity (V max) of lipase, indicating mixed inhibition. AVG considerably inhibits glucose movement across dialysis tubes and was comparable to Arabic gum. AVG was ineffective against the tested microorganisms. Total phenolic and flavonoid contents were 66.06 ± 1.14 (GAE)/mg and 60.95 ± 0.97 (RE)/mg, respectively. AVG a...Continue Reading

References

Jul 1, 1987·The American Journal of Clinical Nutrition·C A EdwardsN W Read
Feb 22, 2008·The Journal of Nutrition·Martin O Weickert, Andreas F H Pfeiffer
Mar 24, 2009·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Kwanghee KimKyungjae Kim
Jan 1, 2007·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·M Umamaheswari, T K Chatterjee
Mar 20, 2010·Critical Reviews in Food Science and Nutrition·Elena Rodríguez RodríguezCarlos Díaz Romero
Mar 31, 2010·Emerging Infectious Diseases·Mohammad I IssackShyam S Manraj
Jul 7, 2010·Journal of the Chinese Medical Association : JCMA·Cheng-Dong ZhengZhi-Gang Ruan
Jul 7, 2011·International Journal of Molecular Sciences·Li FuHua-Bin Li
Jul 28, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Varsha GhadyaleAkalpita Arvindekar
Sep 14, 2011·Oxidative Medicine and Cellular Longevity·O U AmaezeH A B Coker
Mar 27, 2012·Journal of Ethnopharmacology·Damodharan VijayalakshmiAsit Baran Mandal
Jun 12, 2012·Journal of Acupuncture and Meridian Studies·Bahman Nickavar, Naser Esbati
Sep 29, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Márcio Carocho, Isabel C F R Ferreira
Jul 23, 2013·Organic and Medicinal Chemistry Letters·Fatemeh Nejatzadeh-Barandozi
Jan 16, 2014·Journal of Food Science and Technology·Monika ChoudharyJaswinder Sangha
Jul 9, 2014·Annals of Plastic Surgery·Ahmad OryanMohammad Reza Tabandeh

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Citations

Jan 20, 2018·Journal of Complementary & Integrative Medicine·Rajnish Gupta
Aug 15, 2019·Phytotherapy Research : PTR·Mohammad K ParvezAli S Alqahtani
Feb 1, 2020·Current Topics in Medicinal Chemistry·Surriya AminEduardo Sobarzo-Sánchez
Jan 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Surriya AminEduardo Sobarzo-Sánchez

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