Crude extracts of Caenorhabditis elegans suppress airway inflammation in a murine model of allergic asthma.

PloS One
Sung Eun KimMin-Ho Choi

Abstract

Epidemiological studies suggest an inverse relationship between helminth infections and allergic disease, and several helminth-derived products have been shown to suppress allergic responses in animals. This study was undertaken to evaluate the effect of a crude extract of Caenorhabditis elegans on allergic airway inflammation in a murine model of asthma. Allergic airway inflammation was induced in BALB/c mice by sensitization with ovalbumin. The effect of the C. elegans crude extract on the development of asthma and on established asthma was evaluated by analyzing airway hyperresponsiveness, serum antibody titers, lung histology and cell counts and cytokine levels in the bronchoalveolar lavage fluid. The role of IFN-γ in the suppression of asthma by the C. elegans crude extract was investigated in IFN-γ knockout and wild-type mice. When mice were sensitized with ovalbumin together with the crude extract of C. elegans, cellular infiltration into the lung was dramatically reduced in comparison with the ovalbumin-treated group. Treatment of mice with the C. elegans crude extract significantly decreased methacholine-induced airway hyperresponsiveness and the total cell counts and levels of IL-4, IL-5 and IL-13 in the bronchoalveol...Continue Reading

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Citations

Aug 21, 2014·Expert Review of Respiratory Medicine·Katja ObiegloChristian Taube
Mar 1, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·X J YaoS Ying
Oct 16, 2019·Frontiers in Immunology·Sandra CoronadoLuis Caraballo
Sep 10, 2019·Journal of Cellular and Molecular Medicine·Wenzhe ZhangXuefeng Wang
Apr 25, 2019·Drug Delivery and Translational Research·Piyali DeyPronobesh Chattopadhyay
Sep 18, 2020·Journal of Translational Autoimmunity·Belinda M Jackson-ThompsonEdward Mitre

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Methods Mentioned

BETA
light microscopy
ELISA

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