Cry presence and amplitude do not reflect cortical processing of painful stimuli in newborns with distinct responses to touch or cold

Archives of Disease in Childhood. Fetal and Neonatal Edition
Nathalie L MaitreStephen Bruehl

Abstract

Newborns requiring hospitalisation frequently undergo painful procedures. Prevention of pain in infants is of prime concern because of adverse associations with physiological and neurological development. However, pain mitigation is currently guided by behavioural observation assessments that have not been validated against direct evidence of pain processing in the brain. The aim of this study was to determine whether cry presence or amplitude is a valid indicator of pain processing in newborns. Prospective observational cohort. Newborn nursery. Healthy infants born at >37 weeks and <42 weeks gestation. We prospectively studied newborn cortical responses to light touch, cold and heel stick, and the amplitude of associated infant vocalisations using our previously published paradigms of time-locked electroencephalogram (EEG) with simultaneous audio recordings. Latencies of cortical peak responses to each of the three stimuli type were significantly different from each other. Of 54 infants, 13 (24%), 19 (35%) and 35 (65%) had cries in response to light touch, cold and heel stick, respectively. Cry in response to non-painful stimuli did not predict cry in response to heel stick. All infants with EEG data had measurable pain respon...Continue Reading

Citations

May 1, 2018·Archives of Disease in Childhood·Robert Scott-Jupp
Jun 24, 2020·European Journal of Pain : EJP·Loreine M L HelmerFrank Lobbezoo
Apr 12, 2021·Early Human Development·Britney BenoitMarsha Campbell-Yeo
Dec 28, 2017·Pediatrics·Ian St James-Roberts

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