Cryfa: a secure encryption tool for genomic data

Bioinformatics
Morteza HosseiniArmando J Pinho

Abstract

The ever-increasing growth of high-throughput sequencing technologies has led to a great acceleration of medical and biological research and discovery. As these platforms advance, the amount of information for diverse genomes increases at unprecedented rates. Confidentiality, integrity and authenticity of such genomic information should be ensured due to its extremely sensitive nature. In this paper, we propose Cryfa, a fast secure encryption tool for genomic data, namely in Fasta, Fastq, VCF, SAM and BAM formats, which is also capable of reducing the storage size of Fasta and Fastq files. Cryfa uses advanced encryption standard (AES) encryption combined with a shuffling mechanism, which leads to a substantial enhancement of the security against low data complexity attacks. Compared to AES Crypt, a general-purpose encryption tool, Cryfa is an industry-oriented tool, which is able to provide confidentiality, integrity and authenticity of data at four times more speed; in addition, it can reduce the file sizes to 1/3. Due to the absence of a method similar to Cryfa, we have simulated its behavior with a combination of encryption and compression tools, for comparison purpose. For instance, our tool is nine times faster than its fa...Continue Reading

References

Aug 8, 2014·Investigative Genetics·Bruce BudowleSamuel Minot
Aug 19, 2017·Science·Karthik A JagadeeshGill Bejerano
Dec 5, 2017·Nature Immunology·Barney S Graham, Nancy J Sullivan
Jan 3, 2018·Molecular Ecology·Teresita M Porter, Mehrdad Hajibabaei

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Citations

Feb 6, 2019·Interdisciplinary Sciences, Computational Life Sciences·Morteza HosseiniArmando J Pinho
May 21, 2020·GigaScience·Morteza HosseiniArmando J Pinho
Dec 29, 2020·Computers in Biology and Medicine·João Rafael AlmeidaJosé Luís Oliveira
Feb 6, 2021·Bioinformatics·Alexander SenfThomas M Keane

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Software Mentioned

Cryfa
Fastq
Fasta
AES Crypt
DELIMINATE
keygen
AES
MFCompress

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