Cryo-Electron Microscopy Uncovers Key Residues within the Core of Alpha-Synuclein Fibrils

ACS Chemical Neuroscience
Ritobrita Chakraborty, Krishnananda Chattopadhyay

Abstract

Recent expeditious advances in the determination of the 3-D structure of fibrils of alpha-synuclein, the intrinsically disordered protein associated with the neurodegenerative Parkinson's disease (PD), have identified amino acid contacts that form the fibril's inter-protofilament interface. The residues that constitute this "steric zipper" interface determine the morphology of the fibrils as well as toxicity of the oligomeric building units or "kernels" which lead to the formation of the protofilaments. The zipper interface houses key amino acid residues involved in familial PD that can be targeted by drug design.

References

Apr 10, 2015·Proceedings of the National Academy of Sciences of the United States of America·Serene W ChenNunilo Cremades
Mar 29, 2016·Nature Structural & Molecular Biology·Marcus D TuttleChad M Rienstra
Jun 27, 2018·Proceedings of the National Academy of Sciences of the United States of America·Francesco Simone RuggeriGiovanni Dietler
Jul 4, 2018·ELife·Ricardo Guerrero-FerreiraHenning Stahlberg

❮ Previous
Next ❯

Citations

Dec 27, 2019·Prion·Vitaly V KushnirovAlexander I Alexandrov

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

Alpha-Synuclein Aggregation

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

Related Papers

Nō to shinkei = Brain and nerve
Takeshi Iwatsubo
Annals of the New York Academy of Sciences
E Zeitler, F Zemlin
ELife
Ricardo Guerrero-FerreiraHenning Stahlberg
Seikagaku. The Journal of Japanese Biochemical Society
Takeshi Iwatsubo
© 2022 Meta ULC. All rights reserved