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Cryo-EM Structures of the XPF-ERCC1 Endonuclease Reveal an Auto-Inhibited Conformation and the Basis for Activation

bioRxiv

Oct 7, 2019

Morgan A JonesNeil Q McDonald

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Abstract

The structure-specific endonuclease XPF-ERCC1 participates in multiple DNA damage repair pathways including nucleotide excision repair (NER) and inter-strand crosslink repair (ICLR). How XPF-ERCC1 is catalytically activated by DNA junction substrates is not currently understood. We repo...read more

Mentioned in this Paper

DNA
DNA Repair
DNA-Binding Proteins
Fanconi Anemia
Electron Microscopy
Nucleotides
ERCC1 protein, human
Surgical Incisions
Enzyme Activity
Xeroderma Pigmentosum, Group F
39
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Cryo-EM Structures of the XPF-ERCC1 Endonuclease Reveal an Auto-Inhibited Conformation and the Basis for Activation

bioRxiv

Oct 7, 2019

Morgan A JonesNeil Q McDonald

DOI: 10.1101/796524

Abstract

The structure-specific endonuclease XPF-ERCC1 participates in multiple DNA damage repair pathways including nucleotide excision repair (NER) and inter-strand crosslink repair (ICLR). How XPF-ERCC1 is catalytically activated by DNA junction substrates is not currently understood. We repo...read more

Mentioned in this Paper

DNA
DNA Repair
DNA-Binding Proteins
Fanconi Anemia
Electron Microscopy
39

Related Papers

Paper Details
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