Cryoballoon versus Radiofrequency Ablation for Atrial Fibrillation: A Meta-analysis of 16 Clinical Trials

Journal of Atrial Fibrillation
Jalaj GargAndrea Natale

Abstract

Introduction: We aimed to study the procedural characteristics, efficacy and safety of cryoballoon ablation (CBA) versus radiofrequency ablation (RFA) for catheter ablation of paroxysmal atrial fibrillation (AF). Methods: A systematic literature search was performed using PubMed, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials to clinical trials comparing CBA and RFA for AF. Outcomes were evaluated for efficacy, procedure characteristics and safety. For each study, odd ratio (OR) and 95% confidence intervals (CIs) were calculated for endpoints for both approaches. Results: We analyzed a total of 9,957 participants (3,369 in the CBA and 6,588 in RFA group) enrolled in 16 clinical trials. No significant difference was observed between CBA and RFA with regards to freedom from atrial arrhythmia at 12-months, recurrent atrial arrhythmias or repeat catheter ablation. CBA group had a significantly higher transient phrenic nerve injury (OR 14.19, 95% CI: 6.92-29.10; p<0.001) and persistent phrenic nerve injury (OR 4.62, 95% CI: 1.97-10.81; p<0.001); and a significantly lower pericardial effusion/cardiac tamponade (OR 0.43, 95% CI: 0.26-0.72; p=0.001), and groin site complications (OR 0.60, 95% CI: 0.38-0.93; ...Continue Reading

References

Dec 10, 2009·Circulation. Arrhythmia and Electrophysiology·Riccardo CappatoElia Biganzoli
Apr 5, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jason G AndradeMarc Dubuc
Mar 6, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Hugh CalkinsDavid Wilber
Jul 9, 2013·The American Journal of Cardiology·Susan ColillaXianchen Liu
Sep 11, 2013·Journal of Cardiovascular Electrophysiology·Mikael HanninenPeter Leong-Sit
Oct 10, 2013·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Nicasio Pérez-CastellanoJulián Pérez-Villacastín
Oct 19, 2013·Journal of Cardiovascular Electrophysiology·Martin SchmidtEllen Hoffmann
Sep 5, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·François JourdaJean-Paul Albenque
Jan 30, 2015·Pacing and Clinical Electrophysiology : PACE·Jeremiah WasserlaufRod S Passman
Apr 4, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Fabien SquaraOlivier Thomas
Oct 28, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Florian StraubeUNKNOWN FREEZE Cohort Investigators
Dec 19, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Martin SchmidtEllen Hoffmann
Jan 29, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Z KhoueiryS Boveda
Apr 5, 2016·The New England Journal of Medicine·Karl-Heinz KuckUNKNOWN FIRE AND ICE Investigators

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Citations

Feb 16, 2018·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Giacomo MugnaiGian-Battista Chierchia
Apr 16, 2018·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Wilber SuDan Wittenberger
Oct 4, 2019·Pacing and Clinical Electrophysiology : PACE·Hugo-Enrique CoutiñoGian-Battista Chierchia

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