Cryobiopsy With Radial UltraSound Guidance (CYRUS): A Pilot Randomized Controlled Study.

Journal of Bronchology & Interventional Pulmonology
Jasleen K PannuFabien Maldonado

Abstract

Major airway bleeding is the most feared complication of transbronchial cryobiopsy (TBC). Radial endobronchial ultrasound (REBUS) has been used to assess the peripheral lung, primarily to identify pulmonary nodules, and also peripheral blood vessels. Using REBUS-guided TBC to avoid peripheral vasculature might reduce bleeding risk. This prospective randomized double-blind pilot trial was designed to investigate the feasibility of study procedures and inform the power calculation and clinical significance of a future large randomized trial. Consecutive TBCs were randomized to be performed with or without REBUS guidance in the same patient. A nonblinded operator obtained each biopsy while a blinded second operator managed the bleeding after each biopsy and determined when hemostasis had been obtained. Feasibility of study procedures and the ability to recruit patients were of primary interest. Time to hemostasis after each biopsy was also examined. Forty TBCs were performed in 10 patients (4 biopsies per patient) over an enrollment period of 6 months. The time to control bleeding between biopsies was not statistically different between intervention and control arms [-14.3 (-120.1 to 92.0) s, P=0.7878]. Mean bleeding time was 139....Continue Reading

References

Feb 28, 2009·Respiration; International Review of Thoracic Diseases·Alexander BabiakMartin Hetzel
Oct 8, 2011·Chest·Jessica S Wang MemoliGerard A Silvestri
Jul 24, 2013·Thorax·I A Du RandUNKNOWN British Thoracic Society Bronchoscopy Guideline Group
Nov 13, 2015·American Journal of Respiratory and Critical Care Medicine·Sara TomassettiVenerino Poletti
Dec 10, 2015·American Journal of Respiratory and Critical Care Medicine·John P HutchinsonRichard B Hubbard
Mar 19, 2016·Current Opinion in Pulmonary Medicine·Venerino PolettiSara Tomassetti
Sep 3, 2016·Archives of Pathology & Laboratory Medicine·Thomas V ColbyVenerino Poletti
Feb 24, 2017·Annals of the American Thoracic Society·David M DiBardinoJamie L Bessich
Mar 23, 2017·Journal of Bronchology & Interventional Pulmonology·Ilya G BerimFawad Chaudry
Aug 11, 2017·Journal of Bronchology & Interventional Pulmonology·Robert J LentzOtis B Rickman
Jul 10, 2019·The European Respiratory Journal·Jasleen PannuOtis B Rickman

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Citations

May 1, 2021·Medicina·Mărioara SimonAntonia Haranguș

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Methods Mentioned

BETA
biopsies
biopsy

Clinical Trials Mentioned

NCT03506295

Software Mentioned

CYRUS

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