PMID: 9557731Apr 29, 1998Paper

Cryoelectron microscopic examination of human immunodeficiency virus type 1 virions with mutations in the cyclophilin A binding loop

Journal of Virology
L B KongP L Stewart

Abstract

The human immunodeficiency virus type 1 capsid protein contains a conserved P217X4PX2PX5P231 motif. Mutation at Pro-222 decreases virion incorporation of cyclophilin A, while mutation at Pro-231 abolishes infectivity. Although viral RNA incorporation and protease cleavage of the Gag precursor were not affected by these mutations, cryoelectron microscopy revealed a loss of virion maturation in P231A particles.

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Citations

Nov 16, 2004·Journal of Virology·Elena SokolskajaJeremy Luban
Mar 18, 2004·Reviews in Medical Virology·Catherine S Adamson, Ian M Jones
Feb 26, 2010·Journal of Virology·Elena SokolskajaJeremy Luban
Aug 30, 2020·Viruses·Alex B Kleinpeter, Eric O Freed
Apr 15, 2003·Journal of Virology·Uta K von SchwedlerWesley I Sundquist
Feb 5, 2021·Journal of Molecular Biology·Yisong DengJames R Williamson
Nov 24, 2019·Proceedings of the National Academy of Sciences of the United States of America·Nairi PezeshkianSchuyler B van Engelenburg
Dec 22, 1999·Journal of Structural Biology·P L StewartJ L Schlessman
Jan 5, 1999·Science·B K GanserW I Sundquist

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