Cryoglobulinemia in Sjögren Syndrome: A Disease Subset that Links Higher Systemic Disease Activity, Autoimmunity, and Local B Cell Proliferation in Mucosa-associated Lymphoid Tissue

The Journal of Rheumatology
Luca QuartuccioGRISS Group

Abstract

To compare systemic disease activity by validated tools, i.e., the European League Against Rheumatism Sjögren Syndrome Disease Activity Index (ESSDAI) and the Clinical ESSDAI (ClinESSDAI) scores, between primary Sjögren syndrome (pSS) with positive serum cryoglobulins and pSS without serum cryoglobulins. There were 825 consecutive patients with pSS who were retrospectively evaluated. The ESSDAI and the ClinESSDAI scores were significantly higher in cryoglobulin-positive patients (p < 0.0001, for both scores). Cryoglobulinemia was significantly associated with these domains: constitutional (p = 0.003), lymphadenopathy (p = 0.007), glandular (p = 0.0002), cutaneous (p < 0.0001), peripheral nervous system (p < 0.0001), hematological (p = 0.004), and biological (p < 0.0001). Cryoglobulin-positive patients show the highest systemic activity in pSS.

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Citations

Sep 6, 2017·Clinical Reviews in Allergy & Immunology·Elena GeneraliCarlo Selmi
Mar 21, 2019·Rheumatology International·José RosasUNKNOWN SJÖGRENSER Group, part of the Spanish Society of Rheumatology Systemic Autoimmune Diseases Study Group (EASSER)
Jul 28, 2019·Expert Review of Clinical Immunology·Salvatore De Vita, Saviana Gandolfo
Oct 2, 2020·Continuum : Lifelong Learning in Neurology·Chafic Karam
May 1, 2018·Frontiers in Medicine·Alessia AlunnoFrancesco Carubbi
Jul 10, 2019·Expert Opinion on Emerging Drugs·Saviana Gandolfo, Salvatore De Vita
Dec 16, 2019·Clinical Rheumatology·Jorge López-MoralesGabriela Hernández-Molina
May 14, 2019·Neurological Research and Practice·Peter BerlitUNKNOWN Consensus Group
Dec 3, 2020·Minerva medica·Elena TreppoSalvatore DE Vita
Feb 23, 2021·Joint, Bone, Spine : Revue Du Rhumatisme·Camille VillonAlain Saraux

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