Abstract
Controlled cold exposure has long been reported to be a cause of panniculitis in cases such as popsicle panniculitis. Cryolipolysis is a new technology that uses cold exposure, or energy extraction, to result in localized panniculitis and modulation of fat. Presently, the Zeltiq cryolipolysis device is FDA cleared for skin cooling, as well as various other indications, but not for lipolysis. There is, however, a pending premarket notification for noninvasive fat layer reduction. Initial animal and human studies have demonstrated significant reductions in the superficial fat layer thickness, ranging from 20% to 80%, following a single cryolipolysis treatment. The decrease in fat thickness occurs gradually over the first 3 months following treatment, and is most pronounced in patients with limited, discrete fat bulges. Erythema of the skin, bruising, and temporary numbness at the treatment site are commonly observed following treatment with the device, though these effects largely resolve in approximately 1 week. To date, there have been no reports of scarring, ulceration, or alterations in blood lipid or liver function profiles. Cryolipolysis is a new, noninvasive treatment option that may be of benefit in the treatment of exces...Continue Reading
References
Dec 1, 1966·Archives of Dermatology·W C DuncanC L Heaton
Sep 1, 1980·Archives of Dermatology·B E BeachamP E Weary
Dec 14, 2006·Lasers in Surgery and Medicine·Pavan K NoothetiMitchel P Goldman
Apr 26, 2007·Lasers in Surgery and Medicine·J Moreno-MoragaJ Royo de la Torre
May 17, 2007·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Neil Sadick, Cynthia Magro
Dec 21, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·David J GoldbergAlexander L Berlin
Oct 28, 2008·Lasers in Surgery and Medicine·Dieter MansteinR Rox Anderson
Dec 19, 2008·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Elliot Lach
Mar 6, 2009·International Journal of Dermatology·A Tülin Güleç
Mar 20, 2009·Aesthetic Plastic Surgery·Sydney R ColemanJohn Allison
Jul 21, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Brian ZelicksonDieter Manstein
Dec 17, 2009·Lasers in Surgery and Medicine·Kenneth B KleinJessica A Preciado
Citations
Jun 23, 2015·The Journal of Investigative Dermatology·Lilit GaribyanR Rox Anderson
Nov 22, 2015·Aesthetic Surgery Journal·Scott A SeamanThomas J Gampper
Feb 7, 2015·Lasers in Surgery and Medicine·Anne Marie Tremaine, Mathew M Avram
Sep 10, 2014·Journal of Cosmetic Dermatology·Chiara MilaneseCarlo Zancanaro
Dec 18, 2013·Lasers in Surgery and Medicine·Gerald E Boey, Jennifer L Wasilenchuk
Jun 24, 2015·Lasers in Medical Science·Rungsima WanitphakdeedechaWoraphong Manuskiatti
Aug 14, 2013·La Revue de médecine interne·L MorardetM-L Sigal
Sep 10, 2015·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·N KrügerG Sattler
Sep 1, 2015·Aesthetic Surgery Journal·William A Stefani
Apr 18, 2012·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Anne TruittKristen M Kelly
Jul 22, 2014·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Jiehoon KimHwa Jung Ryu
Jul 30, 2014·Adipocyte·Hernán Pinto, Graciela Melamed
Jul 13, 2016·Lasers in Medical Science·Ji-Hye ParkWon-Serk Kim
Jul 22, 2016·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·S Y JeongB J Kim
Jul 17, 2013·Aesthetic Surgery Journal·W Grant StevensMichelle A Spring
Jun 28, 2017·Plastic and Reconstructive Surgery·Lucille AdjadjBarbara Hersant
Apr 12, 2018·Journal of Cosmetic Dermatology·Paloma de S OliveiraAlena P Medrado
May 4, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Christine C DierickxValerie Arigon
Sep 27, 2018·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Margit L W Juhász, Ellen S Marmur
Nov 2, 2011·Aesthetic Plastic Surgery·G A FerraroF D'Andrea
Jun 7, 2019·The Australasian Journal of Dermatology·Daniel MazzoniHooman Khorasani
Jan 23, 2020·Archives of Plastic Surgery·Chang Hyun OhJae Hoon Chang
Apr 14, 2020·Journal of Cosmetic Dermatology·Paula Regazzi de GusmãoGustavo Robertson Filippo
Sep 14, 2017·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Bruce Katz, Sean Doherty
Jan 13, 2017·Turkish Journal of Medical Sciences·Abbas Majdabadi, Mohammad Abazari
Sep 4, 2012·Aesthetic Surgery Journal·Mark L JewellJoel Schlessinger
Mar 7, 2014·Aesthetic Surgery Journal·Gordon H SasakiAna Tevez-Ortiz
Nov 30, 2016·Case Reports in Dermatological Medicine·Patricia Froes MeyerLuis Gonzaga de Araujo Neto
Apr 13, 2018·Dermatologic Therapy·Eun Jung KoBeom Joon Kim
Jan 31, 2021·Aesthetic Plastic Surgery·Alain Michon
Jan 6, 2021·Diabetes & Metabolic Syndrome·Hamed KhedmatgozarMajid Ghayour-Mobarhan
Apr 4, 2021·Journal of Cosmetic Dermatology·Jordan V WangRoy G Geronemus
Aug 19, 2021·Aesthetic Plastic Surgery·Ana Clara Campagnolo Real Gonçalves ToledoFranciele Marques Vanderlei
Sep 30, 2021·Plastic and Reconstructive Surgery. Global Open·Prasanthi KandulaMichael S Kaminer