Cryoprecipitate for transfusion: which patients receive it and why? A study of patterns of use across three regions in England

Transfusion Medicine
H TinegateS Stanworth

Abstract

Despite increasing interest in the use of fibrinogen concentrates, cryoprecipitate remains the major source of fibrinogen in England. Understand patterns and indications for use of cryoprecipitate in hospitals from three English regions. Data collection over 3 months from adults, children and neonates receiving cryoprecipitate, including clinical scenario, indications, dose and levels of fibrinogen concentrations pre- and post-transfusion. Four hundred and twenty-three episodes of cryoprecipitate transfusion were analysed from 39 hospitals. Use varied from 0.1 to 4.9 units per 100 red cells transfused. The primary indication was haemorrhage [311 episodes (74%)]. The commonest clinical scenario in all age groups was cardiac surgery, followed by trauma in adults and critical/neonatal care for children. Pre-treatment fibrinogen levels were measured in 322 episodes. In 179 episodes, the level was ≥ 1.0 g L(-1) . Wide variation in practice and dose suggests inconsistent practice and uncertainty in the evidence informing optimal use of cryoprecipitate.

References

Aug 1, 1995·Anesthesia and Analgesia·S T HiippalaE M Vahtera
Apr 29, 2003·British Journal of Haematology·Ian J MackieUNKNOWN Haemostasis and Thrombosis Task Force of the British Committee for Standards in Haematology
Jun 17, 2004·British Journal of Haematology·D F O'ShaughnessyUNKNOWN British Committee for Standards in Haematology, Blood Transfusion Task Force
Sep 30, 2006·Transfusion Medicine Reviews·Dorothy StainsbyUNKNOWN SHOT Steering Group
Jun 23, 2009·Transfusion Medicine Reviews·Jeannie L CallumYulia Lin
Apr 8, 2010·Critical Care : the Official Journal of the Critical Care Forum·Rolf RossaintUNKNOWN Task Force for Advanced Bleeding Care in Trauma
May 12, 2010·British Journal of Haematology·Benny Sørensen, David Bevan
Jul 16, 2010·British Journal of Anaesthesia·D Fries, W Z Martini
Jan 8, 2011·Journal of Thrombosis and Haemostasis : JTH·Y Ozier, B J Hunt
Aug 20, 2011·Transfusion Medicine·B NascimentoJ Callum
Oct 25, 2011·British Journal of Haematology·Ross Davenport, Sirat Khan

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Citations

Apr 15, 2014·British Journal of Haematology·Saad F IdrisMartin Besser
Mar 29, 2016·Transfusion·Laura GreenRebecca Cardigan
Jun 29, 2014·British Journal of Anaesthesia·B NascimentoJ H Levy
Jan 7, 2015·Revista española de anestesiología y reanimación·A BlasiL Puig
May 28, 2013·Lancet·Lorna M Williamson, Dana V Devine
Aug 31, 2019·Nursing Standard·Jo Shorthouse, Sasha Wilson
Aug 15, 2013·The Journal of Trauma and Acute Care Surgery·John B HolcombUNKNOWN PROMMTT Study Group
Oct 22, 2020·CJEM·Barto NascimentoLuis Teodoro Da Luz
Aug 14, 2019·Blood Reviews·Emily K StorchPaul D Mintz
May 11, 2021·Frontiers in Pediatrics·Gemma Louise Crighton, Elise J Huisman
Jun 7, 2021·Current Opinion in Anaesthesiology·James WinearlsNicola Curry

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