Cryoprecipitate transfusions in the neonatal intensive care unit: a performance improvement study to decrease donor exposure

Transfusion
Erin K TkachDavid A Paul

Abstract

The objective of this study was to determine if a change in cryoprecipitate transfusion policy impacts donor exposure and fibrinogen level in a neonatal intensive care unit (NICU) population. The cryoprecipitate policy was changed from transfusing 10ml/kg to a maximum of 1 unit per transfusion in January 2013. Data were obtained via retrospective chart review of all infants receiving cryoprecipitate transfusions from January 2008 to February 2015 in the NICU at Christiana Hospital. A total of 103 neonates received a total of 144 cryoprecipitate transfusions. Before the policy change, term babies were more likely to be exposed to more than one donor compared to preterm babies (75% vs. 6%, p < 0.01). After the policy change, no babies were exposed to greater than one donor per transfusion and there were similar increases in posttransfusion fibrinogen level as before the policy change. Limiting cryoprecipitate transfusions to 1 unit per transfusion decreased donor exposure in infants without negatively impacting posttransfusion fibrinogen levels. This is especially evident in term neonates.

References

Jun 24, 2003·American Journal of Clinical Pathology·Liron PantanowitzLynne Uhl
Dec 27, 2005·Best Practice & Research. Clinical Haematology·Sheila MacLennan, John A J Barbara
Mar 14, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·V L BaerR D Christensen
Jun 23, 2009·Transfusion Medicine Reviews·Jeannie L CallumYulia Lin
Sep 29, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mario MottaMaurizio Radicioni
Oct 8, 2013·Early Human Development·Anne M Kelly, Lorna M Williamson

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