Cryopreservation of human embryos at the morula stage and outcomes after transfer

Fertility and Sterility
Jun TaoNicole Buehler

Abstract

To evaluate the survival rate of human morula embryo freezing and the morphological alterations during freezing, during and after thawing, and their applications in embryo selection. Retrospective observational study. Private infertility clinic. Consecutive patients under age 39 undergoing frozen morula embryo transfers from December 1999 to May 2003. Embryo freezing was performed at the morula stage. Embryo thaw and post-thaw ETs were conducted on the same day, which is equivalent to a day 4 ET. Morphological alterations during freezing and thawing and after thawing. Post-thaw embryo survival rates, transferable rates, pregnancy rates, and implantation rates. Morula embryos showed reversed morphological alterations during the freezing process; these alterations were recovered during thawing or shortly after the thawing. Post-thaw survival rates showed no significant difference between any of the morula substages. However, embryos scored as grade 3, which represented good quality, had significantly higher post-thaw survival and transferable rates than grade 2 and 1 embryos. Patients who received at least one grade 3 embryo had significantly higher pregnancy rates, implantation rates, and ongoing/live birth rates than other grou...Continue Reading

References

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Citations

Jul 28, 2013·Journal of Assisted Reproduction and Genetics·Deirdre Zander-FoxHamish Hamilton
Jul 21, 2011·Journal of Human Reproductive Sciences·Mary Ellen PavoneJohn Zhang
Oct 11, 2011·Fertility and Sterility·Martin IvecVeljko Vlaisavljevic
Oct 6, 2010·Reproductive Biomedicine Online·Semra Kahraman, Zafer Nihat Candan
Apr 30, 2015·Journal of Assisted Reproduction and Genetics·Jonathan D KortBarry R Behr
Aug 16, 2019·Zygote : the Biology of Gametes and Early Embryos·Maryna PetrushkoNatalia Buderatska
Mar 24, 2018·Group & Organization Management·David P Kroon, Niels G Noorderhaven
Mar 21, 2020·Zygote : the Biology of Gametes and Early Embryos·Cem KorkmazElif Ağaçayak
Nov 2, 2019·Reproductive Biology and Endocrinology : RB&E·Ni-Chin TsaiKuo-Chung Lan

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