Cryopreserved-thawed human embryo transfer: spontaneous natural cycle is superior to human chorionic gonadotropin-induced natural cycle

Fertility and Sterility
Human M FatemiPaul Devroey

Abstract

To assess whether there is a difference in the ongoing pregnancy rate after transferring frozen-thawed embryos in natural cycles with spontaneous LH-P rise compared with natural cycles controlled by hCG for final oocyte maturation and ovulation. Randomized controlled trial. Tertiary referral center. A total of 168 patients were assigned randomly to undergo frozen ET on day 3 from October 2007 until November 2008. Finally, analysis was performed in 124 patients; 61 belonged to the spontaneous LH group and 63 to the hCG group. In the spontaneous LH group the transfer was planned 5 days after the LH surge. In the hCG group, the cryopreserve ET was planned 5 days after the administration of 5000 IU of hCG, when an endometrial thickness of ≥7 mm and a follicle of ≥17 mm were present on ultrasound examination. Ongoing pregnancy rate. The study was terminated early, when a prespecified interim analysis found a significantly higher ongoing pregnancy rate in the spontaneous LH group as compared with the hCG group (31.1% vs. 14.3%; difference 16.9%, 95% confidence interval 4.4%-28.8%). The results suggest the superiority of the natural cycle as compared with the natural cycle controlled by hCG administration in cryothawed ET cycles.

Citations

Mar 7, 2012·Journal of Assisted Reproduction and Genetics·Katharina HanckeJürgen M Weiss
Nov 29, 2012·Journal of Assisted Reproduction and Genetics·Pei-Yun KuYuh-Ming Hwu
Aug 11, 2011·Human Reproduction·Paul DevroeyChristophe Blockeel
Jun 12, 2014·Human Reproduction Update·Jemma EvansLuk J F Rombauts
Jun 12, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Miro KasumSlavko Oreškovic
Mar 4, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Raoul OrvietoBaruch Feldman
Aug 13, 2013·Reproductive Biomedicine Online·H M Fatemi, B Popovic-Todorovic
Jan 16, 2016·Journal of Assisted Reproduction and Genetics·Jorge Rodriguez-PurataTanmoy Mukherjee
Mar 2, 2012·Reproductive Biomedicine Online·M Al-AzemiH M Fatemi
Mar 15, 2016·Journal of Assisted Reproduction and Genetics·Raoul OrvietoJigal Haas
Mar 16, 2011·Annals of the New York Academy of Sciences·Antonio CapalboFilippo Ubaldi
Jun 3, 2014·Fertility and Sterility·Daniela Galliano, Antonio Pellicer
Aug 24, 2016·Journal of Assisted Reproduction and Genetics·Hakan YaraliGurkan Bozdag
Jan 25, 2019·Panminerva Medica·Carlos DosoutoPeter Humaidan
Apr 24, 2020·Current Opinion in Obstetrics & Gynecology·Henrique Dall'Agnol, Juan A García Velasco
Jul 2, 2020·Human Fertility : Journal of the British Fertility Society·Matt Noble, Tim Child
Jul 22, 2020·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Cassandra PakesAlex Polyakov
Feb 8, 2019·Reproductive Biology and Endocrinology : RB&E·Alessandro ConfortiCarlo Alviggi
Mar 22, 2020·Journal of Assisted Reproduction and Genetics·David E ReichmanZev Rosenwaks
Apr 11, 2020·Reproductive Medicine and Biology·Ayuko UchikuraHiroshi Nagashima
Apr 30, 2017·Archives of Gynecology and Obstetrics·Lucia CardellicchioWalter Vegetti
Jul 5, 2017·The Cochrane Database of Systematic Reviews·Tarek GhobaraReuben Olugbenga Ayeleke

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.