Cryopreserved tracheal grafts: a review of the literature

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
Avelina Sotres-VegaPatricio Santillán-Doherty

Abstract

Cryopreserved tracheal grafts have been used in several experimental models of long segment replacement. The clinical application of the procedure has been limited due to the fact that contradictory results have been reported. The purpose of this article is to present a review of the literature on tracheal cryopreservation. Despite the fact that most authors indicate that cryopreserved tracheal allografts retain viability and have a low immunological response, though they continue to function after transplantation with good epithelialization and patency, cryopreservation leads to significant damage to cartilage, the degree of which is based on the freezing-storage methods that affect the function and durability of a graft. The long-term storage of cartilage must therefore be investigated in more detail in basic research models of cartilage viability: the evaluation of chondrocyte apoptosis, and the use of different solutions for tracheal cryopreservation other than RPMI-1640, Dulbecco's modified Eagle's, Eurocollins, and TC-199. Furthermore, problems that involve improving the blood supply to the graft after extensive resection and immunosuppression must be resolved before tracheal cryopreservation can become a clinically estab...Continue Reading

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Citations

Feb 1, 2013·Biopreservation and Biobanking·Avelina Sotres-VegaL Felipe Jiménez-García
May 17, 2011·The Journal of Surgical Research·Dae-Hyun KimHwi-Yool Kim
Jul 9, 2010·Revue des maladies respiratoires·E MartinodA Carpentier
Aug 8, 2009·The Journal of Thoracic and Cardiovascular Surgery·Hongcan ShiJun Wu
Jun 28, 2011·Journal of Tissue Engineering and Regenerative Medicine·Nihal E VranaGarrett B McGuinness
May 11, 2012·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Alejandro M BertolottiRoberto R Favaloro
Aug 2, 2012·Acta Cirúrgica Brasileira·Avelina Sotres-VegaJ Alfredo Santibáñez-Salgado
Jul 13, 2016·Journal of Veterinary Medical Education·Avelina Sotres-VegaJ Alfredo Santibañez-Salgado

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