Cryotherapy in reducing pain, trismus, and facial swelling after third-molar surgery: Systematic review and meta-analysis of randomized clinical trials

The Journal of the American Dental Association
Edmundo M do Nascimento-JúniorPaulo Ricardo Saquete Martins-Filho

Abstract

The aim of this systematic review and meta-analysis was to evaluate the efficacy of cryotherapy in reducing pain, trismus, and facial swelling in patients undergoing third-molar surgery. The authors searched for randomized clinical trials in PubMed, Web of Science, SCOPUS, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, Google Scholar, and OpenThesis. Eligibility criteria were population: patients submitted to removal of impacted third molars; intervention and comparison: postoperative cryotherapy versus no cold therapy; and outcomes: primary outcome was postoperative pain, and secondary outcomes were facial swelling and trismus. Eligible studies must have reported at least 1 of the outcomes of interest. After extracting data and assessing quality, the authors performed the meta-analyses. The authors included 6 studies in the quantitative synthesis analysis. Differences in pain intensity were found on postoperative day 2 (weighted mean difference, -0.72; 95% confidence interval, -1.45 to 0.01; P = .05) and postoperative day 3 (weighted mean difference, -0.36; 95% confidence interval, -0.59 to -0.13; P = .002). No evidence was found that cryotherapy was effective in reducing trismus and facial swelling. The q...Continue Reading

Citations

Jul 1, 2020·The Journal of Craniofacial Surgery·Thiago de Santana SantosPaulo Ricardo Saquete Martins-Filho
May 26, 2021·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Jose S Sifuentes-CervantesJoseph E Van Sickels
Jun 16, 2021·Therapeutic Hypothermia and Temperature Management·Graziele Diniz SilvaGladson Ricardo Flor Bertolini

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