PMID: 6171229Sep 1, 1981Paper

Cryptal origin of the intestinal secretion induced in rats by prostaglandin El. Evolution of secretion after a single injection of 5-fluorouracil

Archives internationales de physiologie et de biochimie
N VidonJ J Bernier

Abstract

The intestinal secretions induced by an intrajejunal perfusion of prostaglandin E1 (PGE1) at the rate of 24 gamma/min in anaesthetized male Wistar rats, weighing 200-200 g, were studied during 6 days after a single injection of an antimitotic agent, the 5-fluorouracil (5-FU, 40 mg/kg). 5-FU induced changes in the structure of the intestinal mucosa. The modifications observed in the intestinal secretions of water and sodium induced by PGE1 suggest that these secretions might (a) originate from crypts; (b) be partly reabsorbed by villi. Concerning the endogenous secretions, the intestinal mucosa might act as a secretion-reabsorption system.

References

Aug 15, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E Beubler, H Juan
Mar 1, 1972·The Journal of Pharmacy and Pharmacology·I M Coupar, I McColl
Jan 1, 1970·Annual Review of Physiology·T R Hendrix, T M Bayless
Oct 1, 1969·The Journal of Clinical Investigation·W B GreenoughD Steinberg
Oct 1, 1966·Biochemical Pharmacology·J W RobinsonA Vannotti
Jul 7, 1972·Nature·R Holliday, G M Tarrant

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