Cryptic variation between species and the basis of hybrid performance.

PLoS Biology
Ulises RosasEnrico Coen

Abstract

Crosses between closely related species give two contrasting results. One result is that species hybrids may be inferior to their parents, for example, being less fertile [1]. The other is that F1 hybrids may display superior performance (heterosis), for example with increased vigour [2]. Although various hypotheses have been proposed to account for these two aspects of hybridisation, their biological basis is still poorly understood [3]. To gain further insights into this issue, we analysed the role that variation in gene expression may play. We took a conserved trait, flower asymmetry in Antirrhinum, and determined the extent to which the underlying regulatory genes varied in expression among closely related species. We show that expression of both genes analysed, CYC and RAD, varies significantly between species because of cis-acting differences. By making a quantitative genotype-phenotype map, using a range of mutant alleles, we demonstrate that the species lie on a plateau in gene expression-morphology space, so that the variation has no detectable phenotypic effect. However, phenotypic differences can be revealed by shifting genotypes off the plateau through genetic crosses. Our results can be readily explained if genomes...Continue Reading

References

Sep 1, 1990·Genes & Development·R Carpenter, E S Coen
Oct 31, 1996·Nature·D LuoE Coen
Dec 9, 1998·Nature·S L Rutherford, S Lindquist
Mar 21, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G Gibson, G Wagner
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·E Sucena, D L Stern
Jun 10, 2000·Heredity·M C WhitlockT Hatfield
Nov 21, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·H A Orr, D C Presgraves
Feb 24, 2001·Evolution; International Journal of Organic Evolution·M C Whitlock
Apr 12, 2001·Molecular Ecology·N H Barton
Nov 9, 2001·Annual Review of Genetics·J M Burke, M L Arnold
Apr 9, 2002·Genes & Development·Lisete Galego, Jorge Almeida
Jun 7, 2002·Nature·Christine QueitschSusan Lindquist
Mar 6, 2003·Genetics·Zsuzsanna Schwarz-SommerAndrew Hudson
Jun 14, 2003·Plant Physiology·Silvia GazzaniCaroline Dean
Jul 2, 2003·Molecular Biology and Evolution·Thomas GubitzAndrew Hudson
Oct 3, 2003·The Plant Cell·James A BirchlerNicole C Riddle
Jul 2, 2004·Nature·Patricia J WittkoppAndrew G Clark
Sep 17, 2004·Nature Reviews. Genetics·Greg Gibson, Ian Dworkin
Mar 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Susie B CorleyEnrico Coen
Jul 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Nicolas B LangladeEnrico Coen
Oct 21, 2005·Development·Maria Manuela R CostaEnrico Coen
Jun 1, 1937·Proceedings of the National Academy of Sciences of the United States of America·S Wright
Aug 19, 2006·Science·Annabel C WhibleyEnrico Coen
Jan 24, 2007·Evolution; International Journal of Organic Evolution·Steven Poe
Sep 1, 1948·Genetics·J F Crow
Jan 27, 2007·Genome Research·Nathan M Springer, Robert M Stupar
Aug 4, 2007·The Plant Journal : for Cell and Molecular Biology·Catherine E L BaxterEnrico S Coen
Nov 22, 2007·The Plant Journal : for Cell and Molecular Biology·Caroline WeightRichard Waites
Feb 19, 2008·Nature Genetics·Patricia J WittkoppAndrew G Clark
May 1, 2009·HFSP Journal·Sandra BensmihenEnrico S Coen
May 29, 2009·Genetics·Xu Zhang, Justin O Borevitz

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Citations

Apr 17, 2014·Nature Communications·Ulises RosasMichael D Purugganan
Mar 24, 2011·American Journal of Physiology. Endocrinology and Metabolism·Wendy Foulds MathesDaniel Pomp
Jul 14, 2011·Genetics·John P MaslyMichelle N Arbeitman
Jun 8, 2011·Evolution; International Journal of Organic Evolution·João LourençoSylvain Glémin
Oct 3, 2012·The New Phytologist·M Manuela R CostaAndrew Hudson
Jan 15, 2014·Evolution; International Journal of Organic Evolution·Luis-Miguel ChevinThomas Lenormand
Aug 29, 2012·Current Opinion in Genetics & Development·Marie-Anne Félix
Apr 6, 2012·PloS One·Ulises RosasMargarita Collazo-Ortega
Aug 28, 2010·Nature Reviews. Genetics·Tanita Casci
Oct 21, 2015·PLoS Genetics·Matthew B Taylor, Ian M Ehrenreich
Nov 6, 2020·Evolution; International Journal of Organic Evolution·Hilde SchneemannJohn J Welch
Jan 17, 2012·Plant Physiology·Daniel H ChitwoodNeelima R Sinha
Sep 17, 2021·Evolution; International Journal of Organic Evolution·Joshua S Schiffman, Peter L Ralph

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Datasets Mentioned

BETA
AY954971
X67957

Methods Mentioned

BETA
PCR
PCRs

Software Mentioned

Opticon Monitor
fminsearch
MATLAB
GEM
Procrustes

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