Cryptochrome 2 and phototropin 2 regulate resistance protein-mediated viral defense by negatively regulating an E3 ubiquitin ligase.

Proceedings of the National Academy of Sciences of the United States of America
Rae-Dong JeongPradeep Kachroo

Abstract

Light harvested by plants is essential for the survival of most life forms. This light perception ability requires the activities of proteins termed photoreceptors. We report a function for photoreceptors in mediating resistance (R) protein-derived plant defense. The blue-light photoreceptors, cryptochrome (CRY) 2 and phototropin (PHOT) 2, are required for the stability of the R protein HRT, and thereby resistance to Turnip Crinkle virus (TCV). Exposure to darkness or blue-light induces degradation of CRY2, and in turn HRT, resulting in susceptibility. Overexpression of HRT can compensate for the absence of PHOT2 but not CRY2. HRT does not directly associate with either CRY2 or PHOT2 but does bind the CRY2-/PHOT2-interacting E3 ubiquitin ligase, COP1. Application of the proteasome inhibitor, MG132, prevents blue-light-dependent degradation of HRT, consequently these plants show resistance to TCV under blue-light. We propose that CRY2/PHOT2 negatively regulate the proteasome-mediated degradation of HRT, likely via COP1, and blue-light relieves this repression resulting in HRT degradation.

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Citations

Aug 29, 2013·Journal of Plant Research·Yasuko Kadomura-IshikawaAkira Takahashi
Jan 28, 2012·Journal of Experimental Botany·Saijaliisa KangasjärviGraham Noctor
Feb 9, 2012·Journal of Experimental Botany·Agnieszka Katarzyna BanaśHalina Gabryś
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Oct 11, 2017·Journal of Experimental Botany·Joo Yong KimHak Soo Seo
Aug 29, 2018·Functional & Integrative Genomics·Savannah BeyerMohsen Mohammadi
Aug 29, 2018·Annual Review of Phytopathology·Julia BallyPeter M Waterhouse
May 18, 2019·International Journal of Molecular Sciences·Hexiang LuanDelin Duan
Oct 28, 2014·Frontiers in Plant Science·Laura ZorattiLaura Jaakola
Jan 27, 2016·Journal of Plant Research·Bobin LiuYoshito Oka
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Dec 8, 2016·Molecular Plant Pathology·Bangjun Zhou, Lirong Zeng
Nov 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Na LianTonglin Mao
Jun 13, 2018·Genes & Genomics·Lina WangWenhao Bo
Aug 14, 2018·Frontiers in Plant Science·Panagiotis LymperopoulosRoel Rabara
Jul 23, 2020·Frontiers in Plant Science·Ying ZhaiHanu R Pappu
Jan 9, 2019·Frontiers in Plant Science·Victor D'Amico-Damião, Rogério Falleiros Carvalho
Mar 7, 2013·Journal of Integrative Plant Biology·William J LucasPradeep Kachroo
Mar 8, 2019·Journal of Experimental Botany·Gah-Hyun LimPradeep Kachroo
Nov 16, 2020·Plant, Cell & Environment·Venja M RoeberAnne Cortleven

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