Cryptochromes modulate E2F family transcription factors.

Scientific Reports
Alanna B ChanKatja A Lamia

Abstract

Early 2 factor (E2F) family transcription factors participate in myriad cell biological processes including: the cell cycle, DNA repair, apoptosis, development, differentiation, and metabolism. Circadian rhythms influence many of these phenomena. Here we find that a mammalian circadian rhythm component, Cryptochrome 2 (CRY2), regulates E2F family members. Furthermore, CRY1 and CRY2 cooperate with the E3 ligase complex SKP-CULLIN-FBXL3 (SCFFBXL3) to reduce E2F steady state protein levels. These findings reveal an unrecognized molecular connection between circadian clocks and cell cycle regulation and highlight another mechanism to maintain appropriate E2F protein levels for proper cell growth.

References

May 2, 2003·Nature Reviews. Cancer·Loning Fu, Cheng Chi Lee
Aug 23, 2003·Science·Takuya MatsuoHitoshi Okamura
Nov 13, 2004·The EMBO Journal·Claire AttwoollKristian Helin
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
May 8, 2007·Cell·Tim Hunt, Paolo Sassone-Corsi
Jul 24, 2007·Bioinformatics·Aravind SubramanianJill P Mesirov
Oct 24, 2009·Nature Reviews. Cancer·Hui-Zi ChenGustavo Leone
Aug 16, 2011·Nature Cell Biology·Emilie BlanchetLluis Fajas
Dec 16, 2011·Nature·Katja A LamiaRonald M Evans
May 15, 2012·Cell Cycle·Varija N BudhavarapuWeei-Chin Lin
Nov 16, 2012·Nature·Joseph Bass
Dec 26, 2012·Proceedings of the National Academy of Sciences of the United States of America·Elzbieta KowalskaSteven A Brown
Aug 7, 2013·Trends in Cell Biology·Carrie L PartchJoseph S Takahashi
Oct 9, 2013·Cancer Letters·Fergal C KelleherAnne Maguire
Dec 18, 2013·Science·Tim WangEric S Lander
Aug 12, 2014·Molecular Biology of the Cell·Tetsuya GotohCarla V Finkielstein
Nov 21, 2014·Molecular Biology of the Cell·Tetsuya GotohCarla V Finkielstein
Sep 16, 2015·Fukushima Journal of Medical Science·Wataru Sakamoto, Seiichi Takenoshita
Jan 16, 2016·Cell Systems·Arthur LiberzonPablo Tamayo
Nov 12, 2016·Proceedings of the National Academy of Sciences of the United States of America·Tetsuya GotohCarla V Finkielstein
Nov 15, 2016·Molecular Cell·Anne-Laure HuberKatja A Lamia
Jul 7, 2017·Cell Metabolism·Sabine D JordanKatja A Lamia
Jul 29, 2017·Proceedings of the National Academy of Sciences of the United States of America·Anna KriebsKatja A Lamia
Dec 12, 2018·Proceedings of the National Academy of Sciences of the United States of America·Meng QuSteve A Kay
Jan 19, 2019·Scientific Reports·Stephanie Papp CorreiaKatja A Lamia
May 6, 2019·Nature Reviews. Cancer·Lindsey N Kent, Gustavo Leone

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Citations

Apr 16, 2020·Journal of Pineal Research·Alanna B Chan, Katja A Lamia
Jul 28, 2020·Journal of Neurochemistry·Shashank Bangalore Srikanta, Nicolas Cermakian
Nov 26, 2020·Open Biology·Bethany Mason, Heike Laman
Jun 30, 2021·Proceedings of the National Academy of Sciences of the United States of America·Alanna B ChanKatja A Lamia
Oct 8, 2021·Experimental & Molecular Medicine·Yool Lee

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Datasets Mentioned

BETA
GSE89018

Methods Mentioned

BETA
ubiquitination
co-immunoprecipitation
immunoprecipitation
nuclear translocation
biopsies
transfection
co-IP

Software Mentioned

GSEA
Gene Set Enrichment Analysis

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Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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