Cryptococcosis: epidemiology, fungal resistance, and new alternatives for treatment

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
Fernanda Patrícia GulloAna Marisa Fusco-Almeida

Abstract

Cryptococcosis is an important systemic mycosis and the third most prevalent disease in human immunodeficiency virus (HIV)-positive individuals. The incidence of cryptococcosis is high among the 25 million people with HIV/acquired immunodeficiency syndrome (AIDS), with recent estimates indicating that there are one million cases of cryptococcal meningitis globally per year in AIDS patients. In Cryptococcus neoformans, resistance to azoles may be associated with alterations in the target enzyme encoded by the gene ERG11, lanosterol 14α-demethylase. These alterations are obtained through mutations, or by overexpressing the gene encoding. In addition, C. gattii and C. neoformans present a heteroresistance phenotype, which may be related to increased virulence. Other species beyond C. neoformans and C. gattii, such as C. laurentii, have been diagnosed mainly in patients with immunosuppression. Infections of C. albidus have been isolated in cats and marine mammals. Recent evidence suggests that the majority of infections produced by this pathogen are associated with biofilm growth, which is also related with increased resistance to antifungal agents. Therefore, there is a great need to search for alternative antifungal agents for th...Continue Reading

References

Jan 1, 1975·Chemotherapy·A Polak, H J Scholer
Nov 1, 1992·Infection and Immunity·J MukherjeeA Casadevall
Aug 1, 1991·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·K J Kwon-Chung
Mar 1, 1990·Reviews of Infectious Diseases·H A GallisW W Pickard
Jul 1, 1995·Antimicrobial Agents and Chemotherapy·J MukherjeeA Casadevall
Jan 1, 1995·Antimicrobial Agents and Chemotherapy·J H RexM A Pfaller
May 1, 1996·Clinical and Experimental Immunology·K KawakamiA Saito
Jun 1, 1996·Intensive Care Medicine·A Bach
Oct 23, 1997·Antimicrobial Agents and Chemotherapy·P MarichalP Mose-Larsen
Mar 25, 1998·The Journal of Antimicrobial Chemotherapy·C J Clancy, M H Nguyen
Apr 29, 1998·Antimicrobial Agents and Chemotherapy·K V Clemons, D A Stevens
Aug 3, 1999·Antimicrobial Agents and Chemotherapy·P MondonK J Kwon-Chung
Apr 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M S SaagW E Dismukes
Sep 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S ChenK Byth
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C P Taborda, A Casadevall
Feb 13, 2001·Trends in Microbiology·T F Mah, G A O'Toole
Feb 22, 2001·Antimicrobial Agents and Chemotherapy·K V ClemonsD A Stevens
Apr 3, 2001·Journal of Clinical Microbiology·M F ChengK S Hsieh
Apr 12, 2002·Lancet·Dimitrios P Kontoyiannis, Russell E Lewis
Jun 1, 2002·The Journal of Antimicrobial Chemotherapy·Gordon RamageJosé L López-Ribot
Feb 27, 2003·Emerging Infectious Diseases·Wieland MeyerUNKNOWN IberoAmerican Cryptococcal Study Group
Feb 27, 2003·Antimicrobial Agents and Chemotherapy·T M Diaz-GuerraJ L Rodriguez-Tudela
Mar 4, 2003·Revista Da Sociedade Brasileira De Medicina Tropical·Wander Fernando de Oliveira FiliúMárcia Lazéra
Apr 5, 2003·Cellular Microbiology·Joshua D Nosanchuk, Arturo Casadevall
Jun 14, 2003·The Journal of Antimicrobial Chemotherapy·F C Odds
Nov 11, 2003·Comprehensive Therapy·Lewis H McCurdy, Jason D Morrow
Feb 26, 2004·Antimicrobial Agents and Chemotherapy·Melissa D JohnsonJohn H Rex
Dec 2, 2004·Proceedings of the National Academy of Sciences of the United States of America·S E KiddW Meyer
Dec 24, 2004·Antimicrobial Agents and Chemotherapy·Brian C MonkDavid R K Harding

❮ Previous
Next ❯

Citations

Feb 25, 2014·Applied Microbiology and Biotechnology·Randy Chi Fai CheungTzi Bun Ng
Feb 20, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Z-W YaoD-F Lin
Nov 25, 2014·Fungal Biology Reviews·Karthik Krishnan, David S Askew
Sep 15, 2015·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Vanessa RiveraTonny Naranjo
Jul 21, 2015·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S A Farber, R G Micheletti
Feb 27, 2015·Cellular and Molecular Life Sciences : CMLS·Muthulekha SwamydasMichail S Lionakis
Dec 3, 2014·Fungal Genetics and Biology : FG & B·Sanjoy PaulW Scott Moye-Rowley
May 29, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Julliana Ribeiro Alves SantosDaniel Assis Santos
Aug 22, 2016·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Aícha Daniela Ribas E RibasAlexandre Meneghello Fuentefria
Jul 13, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A van Belkum
Jul 20, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·X FanZ-Y Liu
Sep 25, 2016·Revista iberoamericana de micología·Diego H CáceresTonny W Naranjo
Mar 31, 2015·ACS Medicinal Chemistry Letters·Soraya Z FerreiraRossimiriam P Freitas
Dec 1, 2017·Medical Mycology Journal·Rui Kano
Sep 7, 2017·Future Microbiology·Ana Cerrejón PalancoAna Marisa Fusco-Almeida
Sep 30, 2016·Nature Communications·Kyung-Tae LeeYong-Sun Bahn
Jan 18, 2018·Mycopathologia·Rui KanoHiroshi Kamata
Jun 26, 2014·Mycoses·Alexander MischnikClemens Stockklausner
Jan 31, 2018·Transplantation·Edson AbdalaManuel Cuenca-Estrella
Nov 20, 2019·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Fatma Ben AbidSaad Taj-Aldeen
Jan 11, 2020·Medical Mycology·Thais Furtado Ferreira MagalhãesDaniel Assis Santos
Sep 15, 2020·Medical Mycology·Raimunda Sâmia Nogueira BrilhanteMarcos Fábio Gadelha Rocha
Jun 12, 2019·Journal of the Pediatric Infectious Diseases Society·Young June ChoeIan C Michelow
Dec 31, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Y DingX Su
Oct 20, 2017·Frontiers in Pharmacology·Jannyson J B JandúLuís C N da Silva
Jan 31, 2018·Frontiers of Medicine·Min ChenWanqing Liao
Oct 18, 2018·Medical Mycology·Findra SetianingrumDavid W Denning
Jul 27, 2017·Frontiers in Microbiology·Néstor CorreaCecilia V Tapia
Nov 26, 2020·Journal of Fungi·Lucas Weba SoaresMirelle Garcia Silva Bailão
Oct 19, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·María Asunción Pérez-Jacoiste AsínUNKNOWN members of the Cohorte de la Red de Investigación en Sida (CoRIS)

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Revista Do Instituto De Medicina Tropical De São Paulo
Mara C S M Pappalardo, Márcia S C Melhem
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
Einar Andreas Sivertsen, Dag Torfoss
© 2022 Meta ULC. All rights reserved