Cryptococcosis in apparently immunocompetent patients

QJM : Monthly Journal of the Association of Physicians
G LuiC S Cockram

Abstract

Few reports have described the clinical and microbiological features of cryptococcosis in immunocompetent patients. To compare clinical presentations and outcomes of cryptococcosis in immunocompetent vs. immunocompromised patients. Retrospective case series. All culture- or histology-confirmed cases (n = 46) of cryptococcosis in two acute hospitals in Hong Kong (1995-2005) were included. Clinical presentations, rates of fungaemia, cerebrospinal fluid (CSF) parameters and clinical outcomes were recorded. Twenty patients (43.5%) were apparently immunocompetent, 17 (37.0%) had predisposing factors other than HIV infection, and 9 (19.6%) were HIV-positive. Thirty-one (67.4%) presented with meningitis, four (8.7%) with pulmonary cryptococcosis, and 11 (23.9%) with extraneural, extrapulmonary cryptococcosis. Of the immunocompetent patients with retrievable isolates (n = 8), three (37.5%) were Cryptococcus gattii; all isolates (n = 6) from immunocompromised patients were Cryptococcus neoformans var. grubii. Immunocompetent patients more commonly presented with meningitis (80.0% vs. 47.1%, p = 0.03), and tended toward lower rates of fungaemia (10.0% vs. 35.3%, p = 0.06) and mortality (25.0% vs. 52.9%, p = 0.06). Death was associated wi...Continue Reading

Citations

Mar 7, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Y LiuX Chen
Oct 1, 2008·Journal of Veterinary Internal Medicine·K A HartM H Barton
Mar 5, 2013·PloS One·Vasilios PyrgosPeter R Williamson
Apr 25, 2013·PloS One·Hsiang-Kuang TsengUNKNOWN Taiwan Infectious Diseases Study Network for Cryptococcosis
Sep 7, 2012·Case Reports in Pathology·S SuchithaG V Manjunath
Aug 30, 2008·Annals of Tropical Paediatrics·A L T MaC W Leung
Apr 5, 2013·Acta neurologica Belgica·Abdul Qayyum RanaAfshan N Rana
Sep 24, 2011·Medical Mycology·Julie HarrisTom Chiller
Sep 13, 2011·Medical Mycology·Monica A Slavin, Arunaloke Chakrabarti
Jun 13, 2014·BMJ Case Reports·Joana PortelinhaJoão Marques Costa
Apr 30, 2014·Lung India : Official Organ of Indian Chest Society·Manoj Kumar PanigrahiSaka Vinod Kumar
Oct 7, 2014·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Angelina Espino Barros PalauAndrew G Lee
Jun 11, 2009·Scandinavian Journal of Infectious Diseases·Yeong Hun ChoeYong Chul Lee
May 29, 2013·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Yumiko AsanumaAkihiro Sudo
Aug 10, 2010·The American Journal of the Medical Sciences·Evgenia KaganChris H Parsons
May 23, 2012·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Chia-Hung LiaoJen-Hsian Wang
Jan 23, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H ZhengL Zhou
Nov 6, 2012·Neuroimaging Clinics of North America·Suyash MohanGaurang V Shah
Apr 3, 2012·Clinical Neurology and Neurosurgery·Prahlad K SethiEdward Arsura
Dec 11, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Manjunath P PaiRohit Sood
Sep 21, 2006·Infectious Disease Clinics of North America·Methee Chayakulkeeree, John R Perfect
Jun 28, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·W-N ChangC-C Chang
Apr 14, 2012·Internal Medicine Journal·S RajagopalaK Gupta
Sep 21, 2013·Emerging Infectious Diseases·Julie R HarrisBenjamin J Park
Oct 7, 2015·Future Microbiology·Hsiang-Kuang TsengAmbrose Jong
Mar 31, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Songul SenadimDilek Atakli

❮ Previous
Next ❯

Related Concepts

Related Feeds

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
P G PappasW E Dismukes
British Medical Bulletin
Tihana Bicanic, Thomas S Harrison
© 2021 Meta ULC. All rights reserved