PMID: 11341375May 9, 2001Paper

Cryptofolione derivatives from Cryptocarya alba fruits

The Journal of Pharmacy and Pharmacology
Guillermo Schmeda-HirschmannGloria Yaluff

Abstract

Cryptofolione (1) and the new cryptofolione derivative 6-(4,6-dimethoxy-8-phenyl-octa-1,7-dienyl)-4-hydroxy-tetrahydro-pyran-2-one (2) were isolated from the fruits of Cryptocarya alba. The structures were elucidated by spectroscopic methods. Cryptofolione showed activity towards Trypanosoma cruzi trypomastigotes, reducing their number by 77% at 250 microg mL(-1). Cryptofolione showed moderate cytotoxicity in both macrophages and T. cruzi amastigotes. It also displayed a mild inhibitory effect on the promastigote form of Leishmania spp. As both cytotoxic and trypanocidal effects are similar, the compound presented little selectivity in our assay models.

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Citations

Jan 22, 2010·Journal of Natural Medicines·Fera KurniadewiKunio Takahashi
Sep 10, 2003·Journal of Ethnopharmacology·Gabriela Egly FeresinGuillermo Schmeda-Hirschmann
May 7, 2002·Memórias do Instituto Oswaldo Cruz·José Rodriques Coura, Solange L de Castro
Jul 13, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·L G RochaJ M Barbosa-Filho
Jul 22, 2010·Pharmaceutical Biology·Matilde Jimenez-CoelloMaria Salud Perez Gutierrez
Mar 19, 2016·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Carolina GiraldoAlbeiro Restrepo

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