Cryptogenetic liver cirrhosis and prothrombotic mutations - A mere association?

Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva
María Monereo MuñozEmilio González Reimers

Abstract

Thrombin activation and microthrombosis of intrahepatic portal venules is a common feature in liver cirrhosis, due in part to relative protein C deficiency and altered coagulation-anticoagulation-fibrinolysis balance. Extension of this microthrombotic process to larger portal vessels explains the increased incidence of portal vein thrombosis in liver cirrhosis. Thrombin not only leads to thrombosis, but also activates liver stellate cells and promotes fibrogenesis. Also, ischemia associated with thrombosis up-regulates the expression and secretion of growth factors involved in fibrogenesis. The coincidence in a given patient of prothrombotic mutations, such as factor V Leiden or PAI-1 polymorphisms, can accelerate the fibrogenetic process. We hereby present two cases of liver cirrhosis in which etiologic evaluation was negative except for the finding of a factor V Leiden mutation in one case and the 4G/5G PAI polymorphism in the second case. These observations support the hypothesis that these mutations may be involved in the etiology of some cases of cirrhosis, or, at least, accelerate the evolution of the disease. It is therefore convenient to search for the presence of prothrombotic mutations in patients with cryptogenetic c...Continue Reading

References

Mar 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D H AdamsW Newman
Sep 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F MarraH E Abboud
May 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I R WanlessG Levy
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christophe CorpechotOlivier Rosmorduc
Sep 28, 2002·American Journal of Hematology·Gunay BaltaAytemiz Gurgey
Feb 13, 2004·Thrombosis and Haemostasis·Martine J HollestelleJan A van Mourik
Oct 14, 2004·Gut·J Gillibert DuplantierJ Rosenbaum
Feb 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Armando TripodiPier Mannuccio Mannucci
Oct 30, 2009·Alimentary Pharmacology & Therapeutics·E A TsochatzisA K Burroughs
Apr 6, 2011·Journal of Cellular Physiology·Asish K Ghosh, Douglas E Vaughan
Dec 17, 2011·World Journal of Gastroenterology : WJG·Nitsan MaharshakRan Oren
Apr 16, 2013·Journal of Hepatology·Armando TripodiPier Mannuccio Mannucci

❮ Previous
Next ❯

Citations

Apr 8, 2020·Antimicrobial Agents and Chemotherapy·Su-Hua ZhangBi-Kui Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.