Cryptogenic fibrosing alveolitis and lung cancer: the BTS study

Thorax
J M HarrisPaul Cullinan

Abstract

The risk of lung cancer is often reported to be increased for patients with cryptogenic fibrosing alveolitis (CFA). Vital status was sought for all 588 members of the British Thoracic Society (BTS) cryptogenic fibrosing alveolitis (CFA) study 11 years after entry to the cohort. Observed deaths due to lung cancer were compared with expected deaths using age-, sex- and period-adjusted national rates. The roles of reported asbestos exposure and smoking were also investigated. 488 cohort members (83%) had died; 46 (9%) were certified to lung cancer (ICD9 162). The standardised mortality ratio (SMR) was 7.4 (95% CI 5.4 to 9.9). Stratified analysis showed increased lung cancer mortality among younger subjects, men and ever smokers. Using an independent expert panel, 25 cohort members (4%) were considered to have at least moderate exposure to asbestos; the risk of lung cancer was increased for these subjects (SMR 13.1 (95% CI 3.6 to 33.6)) vs 7.2 (95% CI 5.2 to 9.7) for those with less or no asbestos exposure). Ever smoking was reported by 448 (73%) of the cohort and was considerably higher in men than in women (92% vs 49%; p<0.001). Most persons who died from lung cancer were male (87%), and all but two (96%) had ever smoked. Ever sm...Continue Reading

Citations

Apr 19, 2011·Seminars in Respiratory and Critical Care Medicine·Ping Yang
Nov 20, 2013·Journal of the National Cancer Institute·Meredith S ShielsAnil K Chaturvedi
Mar 27, 2012·Pulmonary Medicine·Chad K OhNestor A Molfino
Aug 11, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Meredith S ShielsEric A Engels
Jun 13, 2014·International Journal of Chronic Obstructive Pulmonary Disease·Andrea PrimianiRichard L Kradin
Apr 18, 2013·International Journal of Clinical Oncology·Naohiro WatanabeYoshinori Hasegawa
May 29, 2014·Mayo Clinic Proceedings·Jay H RyuAndrew H Limper
Mar 30, 2012·Journal of Medical Economics·Harold R CollardElke Hunsche
Mar 18, 2011·Expert Opinion on Emerging Drugs·Moisés SelmanStefania Cerri
Oct 30, 2015·Occupational Medicine·C M BarberD Fishwick
Jan 24, 2015·Annals of Medicine·Paolo SpagnoloCarlo Vancheri
Nov 8, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Nami UekiMasahiro Hiraoka
Nov 26, 2013·The Journal of Thoracic and Cardiovascular Surgery·Toshihiko SatoJapanese Association for Chest Surgery
Jun 7, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Huaping DaiChen Wang
Aug 1, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Toru KimuraKenji Kangawa
Nov 25, 2015·American Journal of Respiratory and Critical Care Medicine·Olivier BardouKeren S Borensztajn
Feb 18, 2014·Respiratory Medicine·Charlotte HyldgaardElisabeth Bendstrup
Nov 3, 2017·The Clinical Respiratory Journal·Yan LiuHuaping Dai
Feb 3, 2018·Interactive Cardiovascular and Thoracic Surgery·Hiroyuki TaoTsuneo Matsumoto
Aug 17, 2018·PloS One·AliReza JafariNezhad, Mohammad Hossein YektaKooshali
Mar 31, 2017·The European Respiratory Journal·Charlotte LeducElisabeth Quoix
Mar 21, 2019·Annals of the American Thoracic Society·Stacey-Ann Whittaker BrownPaolo Boffetta
Apr 17, 2019·Annals of the American Thoracic Society·Stacey-Ann Whittaker BrownJuan Wisnivesky
Feb 13, 2013·Current Opinion in Allergy and Clinical Immunology·Alessandro FiocchiRichard W Weber
May 5, 2020·Journal of Radiation Research·Yasuhito HagiwaraJapan Radiation Oncology Study Group (JROSG) Working Subgroup for Lung and Mediastinal Tumors
Aug 8, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Yet H KhorAnne E Holland
Jun 6, 2017·Intractable & Rare Diseases Research·Changbo SunShun Xu
Mar 11, 2020·Journal of Clinical Medicine·Quentin GibiotJean-Marc Naccache
Nov 20, 2016·Journal of Internal Medicine·C M SköldG Ferrara
Aug 14, 2019·Chest·Stacey-Ann Whittaker BrownJuan Wisnivesky

Related Concepts

Air Pollutants, Environmental
Asbestos
Environmental Exposure
Malignant Neoplasm of Lung
Occupational Diseases
Cigar smoker
Occupational Exposure
Idiopathic Pulmonary Fibrosis
Attention
Male Population Group

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Related Papers

American Journal of Respiratory and Critical Care Medicine
Richard HubbardJ Britton
American Journal of Respiratory and Critical Care Medicine
Harold R CollardIdiopathic Pulmonary Fibrosis Clinical Research Network Investigators
Respirology : Official Journal of the Asian Pacific Society of Respirology
Yuichi OzawaKingo Chida
American Journal of Respiratory and Critical Care Medicine
Roland M du BoisTalmadge E King
© 2021 Meta ULC. All rights reserved